Sequence Detail

ID/Version

Q64018 Q64019 Q5NCT8 Q9R0Y7 Q9R0Y6 (UniProt | EBI)

Last sequence update: 2000-12-08
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Glycine receptor subunit alpha-1;AltName: Full=Glycine receptor 48 kDa subunit;AltName: Full=Glycine receptor strychnine-binding subunit;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 457 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Glra1	glycine receptor, alpha 1 subunit	113	101	3	20

Sequence references in MGI

J:16637 Matzenbach B, et al., Structural analysis of mouse glycine receptor alpha subunit genes. Identification and chromosomal localization of a novel variant. J Biol Chem. 1994 Jan 28;269(4):2607-12
J:18524 Ryan SG, et al., A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse. Nat Genet. 1994 Jun;7(2):131-5
J:21529 Buckwalter MS, et al., A frameshift mutation in the mouse alpha 1 glycine receptor gene (Glra1) results in progressive neurological symptoms and juvenile death. Hum Mol Genet. 1994 Nov;3(11):2025-30
J:42647 Kling C, et al., The frameshift mutation oscillator (Glra1(spd-ot)) produces a complete loss of glycine receptor alpha1-polypeptide in mouse central nervous system. Neuroscience. 1997 May;78(2):411-7
J:108318 Graham BA, et al., Distinct physiological mechanisms underlie altered glycinergic synaptic transmission in the murine mutants spastic, spasmodic, and oscillator. J Neurosci. 2006 May 3;26(18):4880-90
J:117236 Hirzel K, et al., Hyperekplexia phenotype of glycine receptor alpha1 subunit mutant mice identifies Zn(2+) as an essential endogenous modulator of glycinergic neurotransmission. Neuron. 2006 Nov 22;52(4):679-90
J:126843 Haverkamp S, et al., Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit. J Comp Neurol. 2003 Oct 27;465(4):524-39
J:228551 Aguayo LG, et al., Altered sedative effects of ethanol in mice with alpha1 glycine receptor subunits that are insensitive to Gbetagamma modulation. Neuropsychopharmacology. 2014 Oct;39(11):2538-48