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Sequence Detail
ID/Version
Q63961 Q8K100 Q61520 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2019-05-08
Sequence
description
from provider
RecName: Full=Endoglin;AltName: Full=Cell surface MJ7/18 antigen;AltName: CD_antigen=CD105 {ECO:0000303|PubMed:10625534};Flags: Precursor;
Provider SWISS-PROT
Sequence
Polypeptide 653 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Eng endoglin 91 12 7 42
Sequence references in MGI J:16981 Ge AZ, et al., Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand. Gene. 1994 Jan 28;138(1-2):201-6
J:18318 St-Jacques S, et al., Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells. Endocrinology. 1994 Jun;134(6):2645-57
J:73415 Arthur HM, et al., Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. Dev Biol. 2000 Jan 1;217(1):42-53
J:158024 Ray BN, et al., ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. Carcinogenesis. 2010 Mar;31(3):435-41
J:176620 Castonguay R, et al., Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. J Biol Chem. 2011 Aug 26;286(34):30034-46
J:195735 Nolan-Stevaux O, et al., Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies. PLoS One. 2012;7(12):e50920
J:246201 Sugden WW, et al., Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nat Cell Biol. 2017 Jun;19(6):653-665

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory