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Sequence Detail
ID/Version
Q63959 Q62088 E9Q5E5 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2019-05-08
Sequence
description
from provider
RecName: Full=Potassium voltage-gated channel subfamily C member 3;AltName: Full=KSHIIID;AltName: Full=Voltage-gated potassium channel subunit Kv3.3;
Provider SWISS-PROT
Sequence
Polypeptide 769 aa
For this sequence
Source
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Assays
Orthologs Phenotypic
Alleles
Gene Kcnc3 potassium voltage gated channel, Shaw-related subfamily, member 3 40 2 6 5
Sequence references in MGI J:2312 Ghanshani S, et al., Genomic organization, nucleotide sequence, and cellular distribution of a Shaw-related potassium channel gene, Kv3.3, and mapping of Kv3.3 and Kv3.4 to human chromosomes 19 and 1. Genomics. 1992 Feb;12(2):190-6
J:17480 Goldman-Wohl DS, et al., Kv3.3b: a novel Shaw type potassium channel expressed in terminally differentiated cerebellar Purkinje cells and deep cerebellar nuclei. J Neurosci. 1994 Feb;14(2):511-22
J:71179 Espinosa F, et al., Alcohol hypersensitivity, increased locomotion, and spontaneous myoclonus in mice lacking the potassium channels Kv3.1 and Kv3.3. J Neurosci. 2001 Sep 1;21(17):6657-65
J:100344 McMahon A, et al., Allele-dependent changes of olivocerebellar circuit properties in the absence of the voltage-gated potassium channels Kv3.1 and Kv3.3. Eur J Neurosci. 2004 Jun;19(12):3317-27
J:123641 Joho RH, et al., Behavioral motor dysfunction in Kv3-type potassium channel-deficient mice. Genes Brain Behav. 2006 Aug;5(6):472-82
J:134973 Hurlock EC, et al., Purkinje-cell-restricted restoration of Kv3.3 function restores complex spikes and rescues motor coordination in Kcnc3 mutants. J Neurosci. 2008 Apr 30;28(18):4640-8
J:139895 Desai R, et al., Protein kinase C modulates inactivation of Kv3.3 channels. J Biol Chem. 2008 Aug 8;283(32):22283-94
J:217960 Irie T, et al., Kv3.3 channels harbouring a mutation of spinocerebellar ataxia type 13 alter excitability and induce cell death in cultured cerebellar Purkinje cells. J Physiol. 2014 Jan 1;592(Pt 1):229-47
J:234410 Zhang Y, et al., Kv3.3 Channels Bind Hax-1 and Arp2/3 to Assemble a Stable Local Actin Network that Regulates Channel Gating. Cell. 2016 Apr 7;165(2):434-48
J:263376 Trinidad JC, et al., Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Mol Cell Proteomics. 2006 May;5(5):914-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory