Sequence Detail

ID/Version

Q63934 Q63954 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=POU domain, class 4, transcription factor 2 {ECO:0000305};AltName: Full=Brain-specific homeobox/POU domain protein 3B; Short=Brain-3B; Short=Brn-3B;AltName: Full=Brn-3.2 {ECO:0000303|PubMed:7904822};

Provider

SWISS-PROT

Sequence

Polypeptide 411 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pou4f2	POU domain, class 4, transcription factor 2	90	165	3	20

Sequence references in MGI

J:16381 Theil T, et al., Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a. Nucleic Acids Res. 1993 Dec 25;21(25):5921-9
J:18174 Theil T, et al., Chromosomal localization and sequences of the murine Brn-3 family of developmental control genes. Cytogenet Cell Genet. 1994;66(4):267-71
J:30561 Theil T, et al., Short isoform of POU factor Brn-3b can form a heterodimer with Brn-3a that is inactive for octamer motif binding. J Biol Chem. 1995 Dec 29;270(52):30958-64
J:32903 Gan L, et al., POU domain factor Brn-3b is required for the development of a large set of retinal ganglion cells. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3920-5
J:33502 Erkman L, et al., Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development. Nature. 1996 Jun 13;381(6583):603-6
J:37869 Smith MD, et al., The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Mol Cell Biol. 1997 Jan;17(1):345-54
J:38139 Dawson SJ, et al., A single amino acid change converts an inhibitory transcription factor into an activator. J Biol Chem. 1996 May 17;271(20):11631-3
J:41168 Turner EE, et al., Brn-3.2: a Brn-3-related transcription factor with distinctive central nervous system expression and regulation by retinoic acid. Neuron. 1994 Jan;12(1):205-18
J:56447 Trieu M, et al., Autoregulatory sequences are revealed by complex stability screening of the mouse brn-3.0 locus. J Neurosci. 1999 Aug 1;19(15):6549-58
J:66507 Erkman L, et al., A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system. Neuron. 2000 Dec;28(3):779-92
J:80078 Gan L, et al., POU domain factor Brn-3b is essential for retinal ganglion cell differentiation and survival but not for initial cell fate specification. Dev Biol. 1999 Jun 15;210(2):469-80
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:139182 Farooqui-Kabir SR, et al., Cardiac expression of Brn-3a and Brn-3b POU transcription factors and regulation of Hsp27 gene expression. Cell Stress Chaperones. 2008 Sep;13(3):297-312
J:182786 Feng L, et al., Brn-3b inhibits generation of amacrine cells by binding to and negatively regulating DLX1/2 in developing retina. Neuroscience. 2011 Nov 10;195:9-20
J:183949 Zou M, et al., Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012 Apr 15;364(2):114-27
J:220735 Wu F, et al., Two transcription factors, Pou4f2 and Isl1, are sufficient to specify the retinal ganglion cell fate. Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):E1559-68
J:233565 Zhang L, et al., RIT2, a neuron-specific small guanosine triphosphatase, is expressed in retinal neuronal cells and its promoter is modulated by the POU4 transcription factors. Mol Vis. 2013;19:1371-86
J:239195 Li R, et al., Isl1 and Pou4f2 form a complex to regulate target genes in developing retinal ganglion cells. PLoS One. 2014;9(3):e92105
J:239205 Schulze-Spate U, et al., Brn3 transcription factors control terminal osteoclastogenesis. J Cell Biochem. 2007 Sep 01;102(1):1-12
J:239207 Budhram-Mahadeo VS, et al., Brn-3b enhances the pro-apoptotic effects of p53 but not its induction of cell cycle arrest by cooperating in trans-activation of bax expression. Nucleic Acids Res. 2006;34(22):6640-52
J:239215 Budhram-Mahadeo V, et al., POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. Mol Cell Biol. 1998 Feb;18(2):1029-41
J:239217 Morris PJ, et al., The opposite and antagonistic effects of the closely related POU family transcription factors Brn-3a and Brn-3b on the activity of a target promoter are dependent on differences in the POU domain. Mol Cell Biol. 1994 Oct;14(10):6907-14