Sequence Detail

ID/Version

Q62441 Q9JKQ9 (UniProt | EBI)

Last sequence update: 2007-09-11
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transducin-like enhancer protein 4;AltName: Full=Grg-4;AltName: Full=Groucho-related protein 4;

Provider

SWISS-PROT

Sequence

Polypeptide 773 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tle4	transducin-like enhancer of split 4	38	124	2	48

Sequence references in MGI

J:35621 Koop KE, et al., Transcripts of Grg4, a murine groucho-related gene, are detected in adjacent tissues to other murine neurogenic gene homologues during embryonic development. Mech Dev. 1996 Sep;59(1):73-87
J:77680 Zhu CC, et al., Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors. Development. 2002 Jun;129(12):2835-49
J:103764 Marcal N, et al., Antagonistic effects of Grg6 and Groucho/TLE on the transcription repression activity of brain factor 1/FoxG1 and cortical neuron differentiation. Mol Cell Biol. 2005 Dec;25(24):10916-29
J:169294 Slorach EM, et al., Zeppo1 is a novel metastasis promoter that represses E-cadherin expression and regulates p120-catenin isoform expression and localization. Genes Dev. 2011 Mar 1;25(5):471-84
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297319 Kogawa M, et al., The paired-box homeodomain transcription factor Pax6 binds to the upstream region of the TRAP gene promoter and suppresses receptor activator of NF-kappaB ligand (RANKL)-induced osteoclast differentiation. J Biol Chem. 2013 Oct 25;288(43):31299-312
J:321038 Xie H, et al., Msx1 homeodomain protein represses the alphaGSU and GnRH receptor genes during gonadotrope development. Mol Endocrinol. 2013 Mar;27(3):422-36