Sequence Detail

ID/Version

Q62432 Q6GU18 Q6VP00 Q9D8P6 (UniProt | EBI)

Last sequence update: 2006-11-14
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Mothers against decapentaplegic homolog 2; Short=MAD homolog 2; Short=Mothers against DPP homolog 2;AltName: Full=Mad-related protein 2; Short=mMad2;AltName: Full=SMAD family member 2; Short=SMAD 2; Sh

Provider

SWISS-PROT

Sequence

Polypeptide 467 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Smad2	SMAD family member 2	154	168	3	49

Sequence references in MGI

J:34765 Baker JC, et al., A novel mesoderm inducer, Madr2, functions in the activin signal transduction pathway. Genes Dev. 1996 Aug 1;10(15):1880-9
J:43006 Devereux TR, et al., Smad4 (homolog of human DPC4) and Smad2 (homolog of human JV18-1): candidates for murine lung tumor resistance and suppressor genes. Carcinogenesis. 1997 Sep;18(9):1751-5
J:60559 Shoji H, et al., Identification and characterization of a PDZ protein that interacts with activin type II receptors. J Biol Chem. 2000 Feb 25;275(8):5485-92
J:61302 Weinstein M, et al., Functions of mammalian Smad genes as revealed by targeted gene disruption in mice. Cytokine Growth Factor Rev. 2000 Mar-Jun;11(1-2):49-58
J:65990 Miura S, et al., Hgs (Hrs), a FYVE domain protein, is involved in smad signaling through cooperation with SARA. Mol Cell Biol. 2000 Dec;20(24):9346-55
J:79484 Jiao K, et al., Identification of mZnf8, a Mouse Kruppel-Like Transcriptional Repressor, as a Novel Nuclear Interaction Partner of Smad1. Mol Cell Biol. 2002 Nov;22(21):7633-44
J:92664 Lin HK, et al., Cytoplasmic PML function in TGF-beta signalling. Nature. 2004 Sep 9;431(7005):205-11
J:95374 Dunn NR, et al., Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes Dev. 2005 Jan 1;19(1):152-63
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:122005 Mavrakis KJ, et al., Arkadia Enhances Nodal/TGF-beta Signaling by Coupling Phospho-Smad2/3 Activity and Turnover. PLoS Biol. 2007 Mar 6;5(3):e67
J:169049 Varelas X, et al., The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-beta-SMAD pathway. Dev Cell. 2010 Dec 14;19(6):831-44
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:338226 Zhang Y, et al., Effects of transforming growth factor-beta1 on odontoblastic differentiation in dental papilla cells is determined by IPO7 expression level. Biochem Biophys Res Commun. 2021 Mar 19;545:105-111