Sequence Detail

ID/Version

Q62232 P70179 (UniProt | EBI)

Last sequence update: 1998-07-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Homeobox protein SIX2;AltName: Full=Sine oculis homeobox homolog 2;

Provider

SWISS-PROT

Sequence

Polypeptide 296 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Six2	sine oculis-related homeobox 2	61	192	4	11

Sequence references in MGI

J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
J:35368 Kawakami K, et al., Identification and expression of six family genes in mouse retina. FEBS Lett. 1996 Sep 16;393(2-3):259-63
J:115344 Self M, et al., Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
J:124751 Buller C, et al., Molecular effects of Eya1 domain mutations causing organ defects in BOR syndrome. Hum Mol Genet. 2001 Nov 15;10(24):2775-81
J:135823 Kutejova E, et al., Six2 functions redundantly immediately downstream of Hoxa2. Development. 2008 Apr;135(8):1463-70
J:148455 Kobayashi A, et al., Six2 defines and regulates a multipotent self-renewing nephron progenitor population throughout mammalian kidney development. Cell Stem Cell. 2008 Aug 7;3(2):169-81
J:153643 Self M, et al., Six2 activity is required for the formation of the mammalian pyloric sphincter. Dev Biol. 2009 Oct 15;334(2):409-17
J:154470 Yallowitz AR, et al., Non-homeodomain regions of Hox proteins mediate activation versus repression of Six2 via a single enhancer site in vivo. Dev Biol. 2009 Nov 1;335(1):156-65
J:163483 He G, et al., Inactivation of Six2 in mouse identifies a novel genetic mechanism controlling development and growth of the cranial base. Dev Biol. 2010 Aug 15;344(2):720-30
J:171512 Karner CM, et al., Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. Development. 2011 Apr;138(7):1247-57
J:188777 Park JS, et al., Six2 and Wnt regulate self-renewal and commitment of nephron progenitors through shared gene regulatory networks. Dev Cell. 2012 Sep 11;23(3):637-51
J:208647 Xu J, et al., Osr1 acts downstream of and interacts synergistically with Six2 to maintain nephron progenitor cells during kidney organogenesis. Development. 2014 Apr;141(7):1442-52
J:212814 Ikeda K, et al., Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. Mol Cell Biol. 2002 Oct;22(19):6759-66