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Sequence Detail
Q62231 Q8CIL7 (UniProt | EBI) Last sequence update: 2004-04-13
Last annotation update: 2018-03-28
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RecName: Full=Homeobox protein SIX1;AltName: Full=Sine oculis homeobox homolog 1;
Polypeptide 284 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Six1 sine oculis-related homeobox 1 95 34 9 36
Sequence references in MGI J:23775 Oliver G, et al., Homeobox genes and connective tissue patterning. Development. 1995 Mar;121(3):693-705
J:51236 Spitz F, et al., Expression of myogenin during embryogenesis is controlled by Six/sine oculis homeoproteins through a conserved MEF3 binding site. Proc Natl Acad Sci U S A. 1998 Nov 24;95(24):14220-5
J:82459 Laclef C, et al., Altered myogenesis in Six1-deficient mice. Development. 2003 May;130(10):2239-52
J:83432 Xu PX, et al., Six1 is required for the early organogenesis of mammalian kidney. Development. 2003 Jul;130(14):3085-94
J:84417 Laclef C, et al., Thymus, kidney and craniofacial abnormalities in Six 1 deficient mice. Mech Dev. 2003 Jun;120(6):669-79
J:86619 Li X, et al., Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis. Nature. 2003 Nov 20;426(6964):247-54
J:104488 Ozaki H, et al., Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
J:178379 Richard AF, et al., Genesis of muscle fiber-type diversity during mouse embryogenesis relies on Six1 and Six4 gene expression. Dev Biol. 2011 Nov 15;359(2):303-20
J:212814 Ikeda K, et al., Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. Mol Cell Biol. 2002 Oct;22(19):6759-66

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last database update
MGI 6.12
The Jackson Laboratory