Sequence Detail

ID/Version

Q62230 D3YVZ3 O55216 Q62229 D3YVZ4 Q62228 (UniProt | EBI)

Last sequence update: 2011-09-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Sialoadhesin;AltName: Full=Sheep erythrocyte receptor; Short=SER;AltName: Full=Sialic acid-binding Ig-like lectin 1; Short=Siglec-1;AltName: CD_antigen=CD169;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 1695 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	19	99	2	17

Sequence references in MGI

J:20831 Crocker PR, et al., Sialoadhesin, a macrophage sialic acid binding receptor for haemopoietic cells with 17 immunoglobulin-like domains. EMBO J. 1994 Oct 3;13(19):4490-503
J:44445 Mucklow S, et al., Characterization of the mouse sialoadhesin gene, Sn. Mamm Genome. 1997 Dec;8(12):934-7
J:47306 May AP, et al., Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution. Mol Cell. 1998 Apr;1(5):719-28
J:94072 van den Berg TK, et al., Cutting edge: CD43 functions as a T cell counterreceptor for the macrophage adhesion receptor sialoadhesin (Siglec-1). J Immunol. 2001 Mar 15;166(6):3637-40
J:94999 Kumamoto Y, et al., Identification of sialoadhesin as a dominant lymph node counter-receptor for mouse macrophage galactose-type C-type lectin 1. J Biol Chem. 2004 Nov 19;279(47):49274-80
J:105546 Oetke C, et al., Sialoadhesin-deficient mice exhibit subtle changes in B- and T-cell populations and reduced immunoglobulin M levels. Mol Cell Biol. 2006 Feb;26(4):1549-57
J:226553 Erikson E, et al., Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner. J Biol Chem. 2015 Nov 6;290(45):27345-59
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:318228 Chang YC, et al., Role of macrophage sialoadhesin in host defense against the sialylated pathogen group B Streptococcus. J Mol Med (Berl). 2014 Sep;92(9):951-9