Sequence Detail

ID/Version

Q62227 Q53Z53 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor subfamily 0 group B member 2;AltName: Full=Orphan nuclear receptor SHP;AltName: Full=Small heterodimer partner;

Provider

SWISS-PROT

Sequence

Polypeptide 260 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nr0b2	nuclear receptor subfamily 0, group B, member 2	74	109	4	22

Sequence references in MGI

J:33440 Seol W, et al., An orphan nuclear hormone receptor that lacks a DNA binding domain and heterodimerizes with other receptors. Science. 1996 May 31;272(5266):1336-9
J:84582 Wittenburg H, et al., FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice. Gastroenterology. 2003 Sep;125(3):868-81
J:89077 Kim JY, et al., Orphan nuclear receptor small heterodimer partner, a novel corepressor for a basic helix-loop-helix transcription factor BETA2/neuroD. Mol Endocrinol. 2004 Apr;18(4):776-90
J:97195 Krylova IN, et al., Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11;120(3):343-55
J:122684 Bavner A, et al., A transcriptional inhibitor targeted by the atypical orphan nuclear receptor SHP. EMBO Rep. 2002 May;3(5):478-84
J:170762 Kanamaluru D, et al., Arginine Methylation by PRMT5 at a Naturally Occurring Mutation Site Is Critical for Liver Metabolic Regulation by Small Heterodimer Partner. Mol Cell Biol. 2011 Apr;31(7):1540-50
J:271712 Zhang T, et al., Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity. Theranostics. 2018;8(19):5246-5258
J:274080 Lee SM, et al., Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism. Hepatology. 2015 Feb;61(2):497-505