Sequence Detail

ID/Version

Q62178 D3Z5L2 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Semaphorin-4A;AltName: Full=Semaphorin-B; Short=Sema B;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 760 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sema4a	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A	28	105	3	27

Sequence references in MGI

J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
J:92305 Rice DS, et al., Severe retinal degeneration associated with disruption of semaphorin 4A. Invest Ophthalmol Vis Sci. 2004 Aug;45(8):2767-77
J:97027 Kumanogoh A, et al., Nonredundant Roles of Sema4A in the Immune System: Defective T Cell Priming and Th1/Th2 Regulation in Sema4A-Deficient Mice. Immunity. 2005 Mar;22(3):305-16
J:119828 Toyofuku T, et al., Semaphorin-4A, an activator for T-cell-mediated immunity, suppresses angiogenesis via Plexin-D1. EMBO J. 2007 Mar 7;26(5):1373-84
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:182481 Yukawa K, et al., Sema4A induces cell morphological changes through B-type plexin-mediated signaling. Int J Mol Med. 2010 Feb;25(2):225-30
J:268255 McDermott JE, et al., Class 4 Semaphorins and Plexin-B receptors regulate GABAergic and glutamatergic synapse development in the mammalian hippocampus. Mol Cell Neurosci. 2018 Oct;92:50-66
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89