Sequence Detail

ID/Version

Q62151 C5H7W9 C5H7W6 C5H7W4 C5H3H7 O35444 C5H7W3 C5H3H5 C5H7W8 C5H7W7 C5H7W5 Q2PGG1 C5H3H4 C5H3I0 V5R4Y0 (UniProt | EBI)

Last sequence update: 2016-02-17
Last annotation update: 2025-06-18

Sequence description from provider

RecName: Full=Advanced glycosylation end product-specific receptor;AltName: Full=Receptor for advanced glycosylation end products;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 402 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ager	advanced glycosylation end product-specific receptor	206	104	2	18

Sequence references in MGI

J:55874 Hofmann MA, et al., RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides. Cell. 1999 Jun 25;97(7):889-901
J:86796 Xie T, et al., Analysis of the gene-dense Major Histocompatibility Complex class III region and its comparison to mouse. Genome Res. 2003 Dec;13(12):2621-36
J:115882 Harashima A, et al., Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression. Biochem J. 2006 May 15;396(1):109-15
J:138204 Gao X, et al., AGE/RAGE produces endothelial dysfunction in coronary arterioles in Type 2 diabetic mice. Am J Physiol Heart Circ Physiol. 2008 Aug;295(2):H491-8
J:154746 Takuma K, et al., RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):20021-6
J:169391 Yamamoto Y, et al., Septic shock is associated with receptor for advanced glycation end products ligation of LPS. J Immunol. 2011 Mar 1;186(5):3248-57
J:209684 Jules J, et al., Alternative splicing of the RAGE cytoplasmic domain regulates cell signaling and function. PLoS One. 2013;8(11):e78267
J:244161 Fang F, et al., RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB J. 2010 Apr;24(4):1043-55
J:246356 Kumar V, et al., Homeostatic nuclear RAGE-ATM interaction is essential for efficient DNA repair. Nucleic Acids Res. 2017 Oct 13;45(18):10595-10613
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:308203 Weinhage T, et al., The Receptor for Advanced Glycation Endproducts (RAGE) Contributes to Severe Inflammatory Liver Injury in Mice. Front Immunol. 2020;11:1157
J:359783 Han Z, et al., The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Res. 2023 Mar 21;51(5):2298-2318
J:359792 Yang Y, et al., Receptor for advanced glycation end-products (RAGE) mediates phagocytosis in nonprofessional phagocytes. Commun Biol. 2022 Aug 16;5(1):824