Sequence Detail

ID/Version

Q62141 Q8VDZ5 Q8VCB8 Q6A013 O54976 (UniProt | EBI)

Last sequence update: 2005-06-21
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Paired amphipathic helix protein Sin3b;AltName: Full=Histone deacetylase complex subunit Sin3b;AltName: Full=Transcriptional corepressor Sin3b;

Provider

SWISS-PROT

Sequence

Polypeptide 1098 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sin3b	transcriptional regulator, SIN3B (yeast)	33	106	3	10

Sequence references in MGI

J:29949 Hurlin PJ, et al., Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation. EMBO J. 1995 Nov 15;14(22):5646-59
J:32479 Ayer DE, et al., Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. Cell. 1995 Mar 10;80(5):767-76
J:66140 Spronk CA, et al., The Mad1-Sin3B interaction involves a novel helical fold. Nat Struct Biol. 2000 Dec;7(12):1100-4
J:66985 Laherty CD, et al., SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. Mol Cell. 1998 Jul;2(1):33-42
J:82069 Yang L, et al., An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. Biochem J. 2003 Feb 1;369(Pt 3):651-7
J:84768 Alland L, et al., Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. Mol Cell Biol. 2002 Apr;22(8):2743-50
J:92575 Okazaki N, et al., Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. DNA Res. 2004 Jun 30;11(3):205-18
J:112036 Costa Y, et al., Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34
J:113872 Yang Q, et al., The winged-helix/forkhead protein myocyte nuclear factor beta (MNF-beta) forms a co-repressor complex with mammalian sin3B. Biochem J. 2000 Jan 15;345 Pt 2:335-43
J:162970 Kong Q, et al., RNF220, an E3 ubiquitin ligase that targets Sin3B for ubiquitination. Biochem Biophys Res Commun. 2010 Mar 19;393(4):708-13
J:196237 Shi X, et al., Sin3 interacts with Foxk1 and regulates myogenic progenitors. Mol Cell Biochem. 2012 Jul;366(1-2):251-8
J:209491 Naruse Y, et al., Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation. Mol Cell Biol. 2004 Jul;24(14):6278-87
J:240999 Mall M, et al., Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates. Nature. 2017 Apr 13;544(7649):245-249
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89