Sequence Detail

ID/Version

Q62120 Q62124 G5E852 Q7TQD0 (UniProt | EBI)

Last sequence update: 2021-02-10
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Tyrosine-protein kinase JAK2 {ECO:0000305}; EC=2.7.10.2 {ECO:0000269|PubMed:20304997, ECO:0000269|PubMed:21726629};AltName: Full=Janus kinase 2; Short=JAK-2;

Provider

SWISS-PROT

Sequence

Polypeptide 1132 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Jak2	Janus kinase 2	235	118	4	29

Sequence references in MGI

J:15255 Silvennoinen O, et al., Structure of the murine Jak2 protein-tyrosine kinase and its role in interleukin 3 signal transduction. Proc Natl Acad Sci U S A. 1993 Sep 15;90(18):8429-33
J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
J:25950 Zhao Y, et al., The amino-terminal portion of the JAK2 protein kinase is necessary for binding and phosphorylation of the granulocyte-macrophage colony-stimulating factor receptor beta c chain. J Biol Chem. 1995 Jun 9;270(23):13814-8
J:40444 Witthuhn BA, et al., JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell. 1993 Jul 30;74(2):227-36
J:42354 Wilks AF, Two putative protein-tyrosine kinases identified by application of the polymerase chain reaction. Proc Natl Acad Sci U S A. 1989 Mar;86(5):1603-7
J:47298 Neubauer H, et al., Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998 May 1;93(3):397-409
J:47299 Parganas E, et al., Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1;93(3):385-95
J:124086 Li Z, et al., SH2B1 Enhances Leptin Signaling by Both Janus Kinase 2 Tyr813 Phosphorylation-Dependent and -Independent Mechanisms. Mol Endocrinol. 2007 Sep;21(9):2270-81
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:157074 Guilluy C, et al., The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med. 2010 Feb;16(2):183-90
J:161170 Argetsinger LS, et al., Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity. Mol Endocrinol. 2010 May;24(5):1062-76
J:170821 Berry DC, et al., Signaling by vitamin A and retinol-binding protein regulates gene expression to inhibit insulin responses. Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4340-5
J:190278 Jakel H, et al., Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. Oncogene. 2011 Aug 11;30(32):3502-12
J:200427 Funakoshi-Tago M, et al., Receptor specific downregulation of cytokine signaling by autophosphorylation in the FERM domain of Jak2. EMBO J. 2006 Oct 18;25(20):4763-72
J:200437 Hu J, et al., Structural basis for phosphotyrosine recognition by the Src homology-2 domains of the adapter proteins SH2-B and APS. J Mol Biol. 2006 Aug 4;361(1):69-79
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89