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Sequence Detail
Q62074 (UniProt | EBI) Last sequence update: 2009-06-16
Last annotation update: 2019-05-08
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RecName: Full=Protein kinase C iota type; EC=;AltName: Full=Atypical protein kinase C-lambda/iota; Short=aPKC-lambda/iota;AltName: Full=nPKC-iota;
Polypeptide 595 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Prkci protein kinase C, iota 59 22 9 152
Sequence references in MGI J:17835 Akimoto K, et al., A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem. 1994 Apr 29;269(17):12677-83
J:69174 Joberty G, et al., The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000 Aug;2(8):531-9
J:84324 Imamura T, et al., Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin. Mol Cell Biol. 2003 Jul;23(14):4892-900
J:87746 Bandyopadhyay G, et al., Protein kinase C-lambda knockout in embryonic stem cells and adipocytes impairs insulin-stimulated glucose transport. Mol Endocrinol. 2004 Feb;18(2):373-83
J:92719 Soloff RS, et al., Targeted deletion of protein kinase C lambda reveals a distribution of functions between the two atypical protein kinase C isoforms. J Immunol. 2004 Sep 1;173(5):3250-60
J:102364 Koike C, et al., Function of atypical protein kinase Clambda in differentiating photoreceptors is required for proper lamination of mouse retina. J Neurosci. 2005 Nov 2;25(44):10290-8
J:225407 Fritzius T, et al., WD-repeat-propeller-FYVE protein, ProF, binds VAMP2 and protein kinase Czeta. FEBS J. 2007 Mar;274(6):1552-66
J:225409 Fritzius T, et al., A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda. Biochem J. 2006 Oct 1;399(1):9-20
J:247393 Wang C, et al., Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKCiota in complex with a substrate peptide from Par-3. Structure. 2012 May 09;20(5):791-801

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory