Sequence Detail

ID/Version

Q62073 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase kinase kinase 7; EC=2.7.11.25 {ECO:0000250|UniProtKB:O43318};AltName: Full=Transforming growth factor-beta-activated kinase 1; Short=TGF-beta-activated kinase 1;

Provider

SWISS-PROT

Sequence

Polypeptide 579 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map3k7	mitogen-activated protein kinase kinase kinase 7	112	110	3	58

Sequence references in MGI

J:47270 Yamaguchi K, et al., Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 1995 Dec 22;270(5244):2008-11
J:84524 Li MG, et al., Regulation of the interleukin-1-induced signaling pathways by a novel member of the protein phosphatase 2C family (PP2Cepsilon). J Biol Chem. 2003 Apr 4;278(14):12013-21
J:125855 Reiley WW, et al., Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses. J Exp Med. 2007 Jun 11;204(6):1475-85
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:148055 Blanco S, et al., Vaccinia-related kinase 2 modulates the stress response to hypoxia mediated by TAK1. Mol Cell Biol. 2007 Oct;27(20):7273-83
J:236517 Fujiwara T, et al., PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. JCI Insight. 2016 Oct 20;1(17):e86330
J:244873 Kathania M, et al., Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7. J Immunol. 2015 Mar 01;194(5):2160-7
J:251915 Geng J, et al., Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017 Aug 25;8(1):359
J:261832 Cunningham CA, et al., POSH Regulates CD4+ T Cell Differentiation and Survival. J Immunol. 2016 May 15;196(10):4003-13
J:262344 Ji YX, et al., The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis. Nat Med. 2018 Feb;24(2):213-223
J:279494 Tang Y, et al., K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019 Sep 13;10(1):4157
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:342344 Ma M, et al., TAK1 is an essential kinase for STING trafficking. Mol Cell. 2023 Nov 2;83(21):3885-3903.e5