Sequence Detail

ID/Version

Q61985 O70234 E9Q038 (UniProt | EBI)

Last sequence update: 2013-05-29
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Endoplasmic reticulum membrane sensor NFE2L1 {ECO:0000305};AltName: Full=Locus control region-factor 1 {ECO:0000303|PubMed:9087432}; Short=LCR-F1 {ECO:0000303|PubMed:9087432};AltName: Full=Nuclear factor erythroid 2-related factor 1

Provider

SWISS-PROT

Sequence

Polypeptide 741 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Nfe2l1	nuclear factor, erythroid derived 2,-like 1	81	114	4	32

Sequence references in MGI

J:23248 McKie J, et al., Cloning and mapping of murine Nfe2l1. Genomics. 1995 Feb 10;25(3):716-9
J:39447 Farmer SC, et al., The bZIP transcription factor LCR-F1 is essential for mesoderm formation in mouse development. Genes Dev. 1997 Mar 15;11(6):786-98
J:46990 Chan JY, et al., Targeted disruption of the ubiquitous CNC-bZIP transcription factor, Nrf-1, results in anemia and embryonic lethality in mice. EMBO J. 1998 Mar 16;17(6):1779-87
J:83958 Chen L, et al., Nrf1 is critical for redox balance and survival of liver cells during development. Mol Cell Biol. 2003 Jul;23(13):4673-86
J:86725 Leung L, et al., Deficiency of the Nrf1 and Nrf2 transcription factors results in early embryonic lethality and severe oxidative stress. J Biol Chem. 2003 Nov 28;278(48):48021-9
J:97188 Xu Z, et al., Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4120-5
J:116009 Zhang Y, et al., Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum. Biochem J. 2006 Nov 1;399(3):373-85
J:124618 Xing W, et al., Nuclear factor-E2-related factor-1 mediates ascorbic acid induction of osterix expression via interaction with antioxidant-responsive element in bone cells. J Biol Chem. 2007 Jul 27;282(30):22052-61
J:128023 Zhang Y, et al., The NHB1 (N-terminal homology box 1) sequence in transcription factor Nrf1 is required to anchor it to the endoplasmic reticulum and also to enable its asparagine-glycosylation. Biochem J. 2007 Dec 1;408(2):161-72
J:143468 Ohtsuji M, et al., Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem. 2008 Nov 28;283(48):33554-62
J:148822 Zhang Y, et al., The Nrf1 CNC/bZIP protein is a nuclear envelope-bound transcription factor that is activated by t-butyl hydroquinone but not by endoplasmic reticulum stressors. Biochem J. 2009 Mar 1;418(2):293-310
J:162949 Radhakrishnan SK, et al., Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells. Mol Cell. 2010 Apr 9;38(1):17-28
J:171912 Lee CS, et al., Loss of nuclear factor E2-related factor 1 in the brain leads to dysregulation of proteasome gene expression and neurodegeneration. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8408-13
J:178646 Tsuchiya Y, et al., Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms. Mol Cell Biol. 2011 Nov;31(22):4500-12
J:186656 Hirotsu Y, et al., NF-E2-related factor 1 (Nrf1) serves as a novel regulator of hepatic lipid metabolism through regulation of the Lipin1 and PGC-1beta genes. Mol Cell Biol. 2012 Jul;32(14):2760-70
J:186943 Kobayashi A, et al., Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction. Genes Cells. 2011 Jun;16(6):692-703
J:192355 Kwong EK, et al., Characterization of Nrf1b, a novel isoform of the nuclear factor-erythroid-2 related transcription factor-1 that activates antioxidant response element-regulated genes. PLoS One. 2012;7(10):e48404
J:230118 Hirotsu Y, et al., Transcription factor NF-E2-related factor 1 impairs glucose metabolism in mice. Genes Cells. 2014 Aug;19(8):650-65
J:250015 Widenmaier SB, et al., NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 2017 Nov 16;171(5):1094-1109.e15
J:252001 Biswas M, et al., The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis. J Biol Chem. 2011 Nov 11;286(45):39282-9
J:252061 Myhrstad MC, et al., TCF11/Nrf1 overexpression increases the intracellular glutathione level and can transactivate the gamma-glutamylcysteine synthetase (GCS) heavy subunit promoter. Biochim Biophys Acta. 2001 Jan 26;1517(2):212-9
J:276393 Kwong M, et al., The CNC basic leucine zipper factor, Nrf1, is essential for cell survival in response to oxidative stress-inducing agents. Role for Nrf1 in gamma-gcs(l) and gss expression in mouse fibroblasts. J Biol Chem. 1999 Dec 24;274(52):37491-8