Sequence Detail

ID/Version

Q61880 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2026-09-02

Sequence description from provider

RecName: Full=Meiotic recombination protein DMC1 homolog {ECO:0000305}; EC=3.6.4.- {ECO:0000269|PubMed:17639081};

Provider

SWISS-PROT

Sequence

Polypeptide 340 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dmc1	DNA meiotic recombinase 1	78	138	3	19

Sequence references in MGI

J:31333 Habu T, et al., The mouse and human homologs of DMC1, the yeast meiosis-specific homologous recombination gene, have a common unique form of exon-skipped transcript in meiosis. Nucleic Acids Res. 1996 Feb 1;24(3):470-7
J:32671 Sato S, et al., Characterization of a mouse recA-like gene specifically expressed in testis. DNA Res. 1995 Jun 30;2(3):147-50
J:47307 Yoshida K, et al., The mouse RecA-like gene Dmc1 is required for homologous chromosome synapsis during meiosis. Mol Cell. 1998 Apr;1(5):707-18
J:47308 Pittman DL, et al., Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specific RecA homolog. Mol Cell. 1998 Apr;1(5):697-705
J:170340 Dray E, et al., Molecular basis for enhancement of the meiotic DMC1 recombinase by RAD51 associated protein 1 (RAD51AP1). Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3560-5
J:183982 Wojtasz L, et al., Meiotic DNA double-strand breaks and chromosome asynapsis in mice are monitored by distinct HORMAD2-independent and -dependent mechanisms. Genes Dev. 2012 May 1;26(9):958-73
J:273173 Zhang J, et al., A meiosis-specific BRCA2 binding protein recruits recombinases to DNA double-strand breaks to ensure homologous recombination. Nat Commun. 2019 Feb 13;10(1):722
J:285969 Liu H, et al., SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. Nucleic Acids Res. 2019 Jun 20;47(11):5670-5683
J:291221 Shang Y, et al., MEIOK21: a new component of meiotic recombination bridges required for spermatogenesis. Nucleic Acids Res. 2020 Jul 9;48(12):6624-6639
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:297178 Hinch AG, et al., The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates. Mol Cell. 2020 Aug 20;79(4):689-701.e10
J:297328 Zhang Q, et al., SPO16 binds SHOC1 to promote homologous recombination and crossing-over in meiotic prophase I. Sci Adv. 2019 Jan;5(1):eaau9780
J:330108 Pezza RJ, et al., Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing. Genes Dev. 2007 Jul 15;21(14):1758-66
J:330110 Petukhova GV, et al., The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination. Nat Struct Mol Biol. 2005 May;12(5):449-53
J:342157 Ito M, et al., FIGNL1 AAA+ ATPase remodels RAD51 and DMC1 filaments in pre-meiotic DNA replication and meiotic recombination. Nat Commun. 2023 Oct 27;14(1):6857