Sequence Detail

ID/Version

Q61823 P97296 Q3T9A9 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Programmed cell death protein 4;AltName: Full=Protein MA-3;AltName: Full=Topoisomerase-inhibitor suppressed protein;

Provider

SWISS-PROT

Sequence

Polypeptide 469 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pdcd4	programmed cell death 4	48	101	3	12

Sequence references in MGI

J:30309 Shibahara K, et al., Isolation of a novel mouse gene MA-3 that is induced upon programmed cell death. Gene. 1995 Dec 12;166(2):297-301
J:49527 Onishi Y, et al., Molecular cloning of the genes suppressed in RVC lymphoma cells by topoisomerase inhibitors. Biochem Biophys Res Commun. 1996 Nov 1;228(1):7-13
J:49547 Onishi Y, et al., Cloning of the TIS gene suppressed by topoisomerase inhibitors. Gene. 1998 Jul 30;215(2):453-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100086 Jansen AP, et al., Epidermal expression of the translation inhibitor programmed cell death 4 suppresses tumorigenesis. Cancer Res. 2005 Jul 15;65(14):6034-41
J:109581 Clee SM, et al., Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus. Nat Genet. 2006 Jun;38(6):688-93
J:113966 Yang HS, et al., The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Mol Cell Biol. 2003 Jan;23(1):26-37
J:145850 Loh PG, et al., Structural basis for translational inhibition by the tumour suppressor Pdcd4. EMBO J. 2009 Feb 4;28(3):274-85
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89