Sequence Detail

ID/Version

Q61730 Q3UVZ1 Q8VCB9 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Interleukin-1 receptor accessory protein; Short=IL-1 receptor accessory protein; Short=IL-1RAcP; EC=3.2.2.6 {ECO:0000255|PROSITE-ProRule:PRU00204};AltName: Full=Interleukin-33 receptot beta chain {ECO:0000303|PubMed:1

Provider

SWISS-PROT

Sequence

Polypeptide 570 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Il1rap	interleukin 1 receptor accessory protein	48	103	2	14

Sequence references in MGI

J:25951 Greenfeder SA, et al., Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J Biol Chem. 1995 Jun 9;270(23):13757-65
J:64697 Burns K, et al., Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol. 2000 Jun;2(6):346-51
J:76518 Radons J, et al., Identification of essential regions in the cytoplasmic tail of interleukin-1 receptor accessory protein critical for interleukin-1 signaling. J Biol Chem. 2002 May 10;277(19):16456-63
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:127627 Ali S, et al., IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells. Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18660-5
J:150078 Smith DE, et al., A central nervous system-restricted isoform of the interleukin-1 receptor accessory protein modulates neuronal responses to interleukin-1. Immunity. 2009 Jun 19;30(6):817-31
J:151287 Chackerian AA, et al., IL-1 receptor accessory protein and ST2 comprise the IL-33 receptor complex. J Immunol. 2007 Aug 15;179(4):2551-5
J:160247 Drube S, et al., The receptor tyrosine kinase c-Kit controls IL-33 receptor signaling in mast cells. Blood. 2010 May 13;115(19):3899-906
J:172530 Yasuoka S, et al., Production and functions of IL-33 in the central nervous system. Brain Res. 2011 Apr 18;1385:8-17
J:186478 Qian J, et al., Interleukin-1R3 mediates interleukin-1-induced potassium current increase through fast activation of Akt kinase. Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12189-94
J:222796 Yamagata A, et al., Mechanisms of splicing-dependent trans-synaptic adhesion by PTPdelta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun. 2015;6:6926
J:298383 Huang Y, et al., Neuron-specific effects of interleukin-1beta are mediated by a novel isoform of the IL-1 receptor accessory protein. J Neurosci. 2011 Dec 7;31(49):18048-59