Sequence Detail

ID/Version

Q61701 A2A9S2 Q8BVA9 A2A9S0 A2A9S1 A2A9R7 Q6PHZ3 A2A9R8 A2A9S3 A2A9R6 O55010 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=ELAV-like protein 4;AltName: Full=Hu-antigen D; Short=HuD;AltName: Full=Paraneoplastic encephalomyelitis antigen HuD;

Provider

SWISS-PROT

Sequence

Polypeptide 385 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Elavl4	ELAV like RNA binding protein 4	47	138	3	10

Sequence references in MGI

J:31495 Abe R, et al., Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. DNA Res. 1994;1(4):175-80
J:40252 Inman MV, et al., Gene organization and chromosome location of the neural-specific RNA binding protein Elavl4. Gene. 1998 Feb 27;208(2):139-45
J:62325 Okano HJ, et al., A hierarchy of Hu RNA binding proteins in developing and adult neurons. J Neurosci. 1997 May 1;17(9):3024-37
J:97282 Akamatsu W, et al., The RNA-binding protein HuD regulates neuronal cell identity and maturation. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4625-30
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:107115 Ratti A, et al., A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of Msi1 mRNA. J Cell Sci. 2006 Apr 1;119(Pt 7):1442-1452
J:117945 Zhu H, et al., A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators. Mol Biol Cell. 2006 Dec;17(12):5105-14
J:170079 Fallini C, et al., The Survival of Motor Neuron (SMN) Protein Interacts with the mRNA-Binding Protein HuD and Regulates Localization of Poly(A) mRNA in Primary Motor Neuron Axons. J Neurosci. 2011 Mar 9;31(10):3914-25
J:187725 Bronicki LM, et al., Characterization of Multiple Exon 1 Variants in Mammalian HuD mRNA and Neuron-Specific Transcriptional Control via Neurogenin 2. J Neurosci. 2012 Aug 15;32(33):11164-75
J:195779 Allen M, et al., HuD promotes BDNF expression in brain neurons via selective stabilization of the BDNF long 3'UTR mRNA. PLoS One. 2013;8(1):e55718
J:209618 DeBoer EM, et al., Prenatal deletion of the RNA-binding protein HuD disrupts postnatal cortical circuit maturation and behavior. J Neurosci. 2014 Mar 5;34(10):3674-86
J:226807 Wang F, et al., Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis. Proc Natl Acad Sci U S A. 2015 Sep 8;112(36):E4995-5004
J:238885 Vanevski F, et al., HuD interacts with Bdnf mRNA and is essential for activity-induced BDNF synthesis in dendrites. PLoS One. 2015;10(2):e0117264
J:289071 Ratti A, et al., Post-transcriptional regulation of neuro-oncological ventral antigen 1 by the neuronal RNA-binding proteins ELAV. J Biol Chem. 2008 Mar 21;283(12):7531-41
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89