Sequence Detail

ID/Version

Q61616 Q8C8P8 B2RPW8 (UniProt | EBI)

Last sequence update: 2003-05-30
Last annotation update: 2026-09-02

Sequence description from provider

RecName: Full=Dopamine receptor D1 {ECO:0000305};AltName: Full=Dopamine D1 receptor;

Provider

SWISS-PROT

Sequence

Polypeptide 446 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Drd1	dopamine receptor D1	223	112	4	34

Sequence references in MGI

J:15563 Wilkie TM, et al., Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors. Genomics. 1993 Nov;18(2):175-84
J:21603 Xu M, et al., Dopamine D1 receptor mutant mice are deficient in striatal expression of dynorphin and in dopamine-mediated behavioral responses. Cell. 1994 Nov 18;79(4):729-42
J:48769 Smith DR, et al., Behavioural assessment of mice lacking D1A dopamine receptors. Neuroscience. 1998 Sep;86(1):135-46
J:67395 El-Ghundi M, et al., Prolonged fear responses in mice lacking dopamine D(1) receptor. Brain Res. 2001 Feb 16;892(1):86-93
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112986 Xu M, et al., Elimination of cocaine-induced hyperactivity and dopamine-mediated neurophysiological effects in dopamine D1 receptor mutant mice. Cell. 1994 Dec 16;79(6):945-55
J:224553 Jung G, et al., Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus. J Neurochem. 2015 Jul;134(2):327-39
J:228021 Kern A, et al., Hippocampal Dopamine/DRD1 Signaling Dependent on the Ghrelin Receptor. Cell. 2015 Nov 19;163(5):1176-90
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:344895 Jia J, et al., Gm527 deficiency in dentate gyrus improves memory through upregulating dopamine D1 receptor pathway. CNS Neurosci Ther. 2023 Nov;29(11):3290-3306
J:363155 Cai X, et al., Dopamine dynamics are dispensable for movement but promote reward responses. Nature. 2024 Nov;635(8038):406-414
J:370672 Godino A, et al., Dopamine D1-D2 signalling in hippocampus arbitrates approach and avoidance. Nature. 2025 Jul;643(8071):448-457