Sequence Detail

ID/Version

Q61539 O09146 A2RTQ7 O09067 Q8C7A6 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Steroid hormone receptor ERR2 {ECO:0000305};AltName: Full=Estrogen receptor-like 2;AltName: Full=Estrogen-related receptor beta {ECO:0000250|UniProtKB:O95718}; Short=ERR-beta;AltName: Full=Nuclear receptor subfamily 3 group B member

Provider

SWISS-PROT

Sequence

Polypeptide 433 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Esrrb	estrogen related receptor, beta	67	133	3	171

Sequence references in MGI

J:31609 Pettersson K, et al., Expression of a novel member of estrogen response element-binding nuclear receptors is restricted to the early stages of chorion formation during mouse embryogenesis. Mech Dev. 1996 Feb;54(2):211-23
J:42488 Luo J, et al., Placental abnormalities in mouse embryos lacking the orphan nuclear receptor ERR-beta. Nature. 1997 Aug 21;388(6644):778-82
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:124941 Chen J, et al., Estrogen-Related Receptor beta/NR3B2 Controls Epithelial Cell Fate and Endolymph Production by the Stria Vascularis. Dev Cell. 2007 Sep;13(3):325-37
J:140350 van den Berg DL, et al., Estrogen-related receptor beta interacts with Oct4 to positively regulate Nanog gene expression. Mol Cell Biol. 2008 Oct;28(19):5986-95
J:161283 Onishi A, et al., The orphan nuclear hormone receptor ERRbeta controls rod photoreceptor survival. Proc Natl Acad Sci U S A. 2010 Jun 22;107(25):11579-84
J:188268 Percharde M, et al., Ncoa3 functions as an essential Esrrb coactivator to sustain embryonic stem cell self-renewal and reprogramming. Genes Dev. 2012 Oct 15;26(20):2286-98
J:193651 Martello G, et al., Esrrb is a pivotal target of the Gsk3/Tcf3 axis regulating embryonic stem cell self-renewal. Cell Stem Cell. 2012 Oct 5;11(4):491-504
J:204034 Uranishi K, et al., Dax1 associates with Esrrb and regulates its function in embryonic stem cells. Mol Cell Biol. 2013 May;33(10):2056-66
J:238558 Festuccia N, et al., Mitotic binding of Esrrb marks key regulatory regions of the pluripotency network. Nat Cell Biol. 2016 Nov;18(11):1139-1148
J:239004 Uranishi K, et al., Esrrb directly binds to Gata6 promoter and regulates its expression with Dax1 and Ncoa3. Biochem Biophys Res Commun. 2016 Sep 30;478(4):1720-5
J:240259 Hutchins AP, et al., Co-motif discovery identifies an Esrrb-Sox2-DNA ternary complex as a mediator of transcriptional differences between mouse embryonic and epiblast stem cells. Stem Cells. 2013 Feb;31(2):269-81
J:240260 Festuccia N, et al., Esrrb is a direct Nanog target gene that can substitute for Nanog function in pluripotent cells. Cell Stem Cell. 2012 Oct 05;11(4):477-90
J:240273 Zhang X, et al., Esrrb activates Oct4 transcription and sustains self-renewal and pluripotency in embryonic stem cells. J Biol Chem. 2008 Dec 19;283(51):35825-33
J:240581 Iseki H, et al., Combined Overexpression of JARID2, PRDM14, ESRRB, and SALL4A Dramatically Improves Efficiency and Kinetics of Reprogramming to Induced Pluripotent Stem Cells. Stem Cells. 2016 Feb;34(2):322-33
J:240583 Latos PA, et al., Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Nat Commun. 2015 Jul 24;6:7776
J:241127 Real MA, et al., Efferent retinal projections visualized by immunohistochemical detection of the estrogen-related receptor beta in the postnatal and adult mouse brain. Neurosci Lett. 2008 Jun 13;438(1):48-53