Sequence Detail

ID/Version

Q61527 Q3UNS6 O88460 B2KGF5 B2KGF6 (UniProt | EBI)

Last sequence update: 2012-01-25
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Receptor tyrosine-protein kinase erbB-4; EC=2.7.10.1;AltName: Full=Proto-oncogene-like protein c-ErbB-4;Contains: RecName: Full=ERBB4 intracellular domain; Short=4ICD; Short=E4ICD; AltName: Full=s80HER4;Flags: P

Provider

SWISS-PROT

Sequence

Polypeptide 1308 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Erbb4	erb-b2 receptor tyrosine kinase 4	157	152	5	21

Sequence references in MGI

J:29667 Moscoso LM, et al., Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. Dev Biol. 1995 Nov;172(1):158-69
J:29972 Gassmann M, et al., Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor [see comments]. Nature. 1995 Nov 23;378(6555):390-4
J:43571 Elenius K, et al., A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. J Biol Chem. 1997 Oct 17;272(42):26761-8
J:54899 Elenius K, et al., Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. Oncogene. 1999 Apr 22;18(16):2607-15
J:60190 Golding JP, et al., Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. Nat Cell Biol. 2000 Feb;2(2):103-9
J:84403 Tidcombe H, et al., Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8281-6
J:86319 Long W, et al., Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. Development. 2003 Nov;130(21):5257-68
J:95821 Anton ES, et al., Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. Nat Neurosci. 2004 Dec;7(12):1319-28
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:114489 Muraoka-Cook RS, et al., The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. Mol Biol Cell. 2006 Sep;17(9):4118-29
J:152606 Muraoka-Cook RS, et al., ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. Mol Cell Biol. 2009 Sep;29(18):4935-48
J:157327 Bersell K, et al., Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. Cell. 2009 Jul 23;138(2):257-70
J:178286 Jones FE, et al., ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. J Cell Biol. 1999 Oct 4;147(1):77-88
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89