Sequence Detail

ID/Version

Q61496 Q9D5X7 (UniProt | EBI)

Last sequence update: 2002-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=ATP-dependent RNA helicase DDX4 {ECO:0000305|PubMed:28633017}; EC=3.6.4.13 {ECO:0000305|PubMed:28633017};AltName: Full=DEAD box protein 4;AltName: Full=Mvh {ECO:0000303|PubMed:28254886, ECO:0000303|PubMed:7991615};AltName: Full=Vasa

Provider

SWISS-PROT

Sequence

Polypeptide 702 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ddx4	DEAD box helicase 4	61	241	3	18

Sequence references in MGI

J:21929 Fujiwara Y, et al., Isolation of a DEAD-family protein gene that encodes a murine homolog of Drosophila vasa and its specific expression in germ cell lineage. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12258-62
J:87735 Kuramochi-Miyagawa S, et al., Mili, a mammalian member of piwi family gene, is essential for spermatogenesis. Development. 2004 Feb;131(4):839-49
J:87812 Shibata N, et al., Mouse RanBPM is a partner gene to a germline specific RNA helicase, mouse vasa homolog protein. Mol Reprod Dev. 2004 Jan;67(1):1-7
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112036 Costa Y, et al., Mouse MAELSTROM: the link between meiotic silencing of unsynapsed chromatin and microRNA pathway?. Hum Mol Genet. 2006 Aug 1;15(15):2324-34
J:117063 Hosokawa M, et al., Tudor-related proteins TDRD1/MTR-1, TDRD6 and TDRD7/TRAP: domain composition, intracellular localization, and function in male germ cells in mice. Dev Biol. 2007 Jan 1;301(1):38-52
J:159518 Kuramochi-Miyagawa S, et al., MVH in piRNA processing and gene silencing of retrotransposons. Genes Dev. 2010 May;24(9):887-92
J:189932 Peruquetti RL, et al., Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells. PLoS One. 2012;7(8):e42695
J:243444 Tarabay Y, et al., Tex19 paralogs are new members of the piRNA pathway controlling retrotransposon suppression. J Cell Sci. 2017 Apr 15;130(8):1463-1474
J:243488 Wenda JM, et al., Distinct Roles of RNA Helicases MVH and TDRD9 in PIWI Slicing-Triggered Mammalian piRNA Biogenesis and Function. Dev Cell. 2017 Jun 19;41(6):623-637.e9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:335610 Qian B, et al., RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis. Sci Adv. 2022 Aug 26;8(34):eabq2945