Sequence Detail

ID/Version

Q61488 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Desert hedgehog protein {ECO:0000305}; Short=DHH; EC=3.1.-.- {ECO:0000250|UniProtKB:Q62226};AltName: Full=HHG-3;Contains: RecName: Full=Desert hedgehog protein N-product;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 396 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dhh	desert hedgehog	57	139	3	12

Sequence references in MGI

J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
J:21621 Chang DT, et al., Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development. 1994 Nov;120(11):3339-53
J:50930 Carpenter D, et al., Characterization of two patched receptors for the vertebrate hedgehog protein family. Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13630-4
J:57341 Parmantier E, et al., Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron. 1999 Aug;23(4):713-24
J:57914 Bitgood MJ, et al., Sertoli cell signaling by Desert hedgehog regulates the male germline. Curr Biol. 1996 Mar 1;6(3):298-304
J:65900 Clark AM, et al., Desert hedgehog (Dhh) gene is required in the mouse testis for formation of adult-type leydig cells and normal development of peritubular cells and seminiferous tubules. Biol Reprod. 2000 Dec;63(6):1825-38
J:290862 Fulmer D, et al., Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin. Dev Biol. 2020 Jul 1;463(1):26-38
J:339285 Hollier PL, et al., Full-length Dhh and N-terminal Shh act as competitive antagonists to regulate angiogenesis and vascular permeability. Cardiovasc Res. 2021 Nov 1;117(12):2489-2501