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Sequence Detail
Q61483 Q6PFV7 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2019-07-31
from provider
RecName: Full=Delta-like protein 1 {ECO:0000305};AltName: Full=Drosophila Delta homolog 1; Short=Delta1 {ECO:0000303|PubMed:12794186};Contains: RecName: Full=Dll1-soluble form {ECO:0000303|PubMed:12794186}; Short=Dll1-EC {ECO:0000305|Pu
Polypeptide 722 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Dll1 delta like canonical Notch ligand 1 109 99 8 38
Sequence references in MGI J:28006 Bettenhausen B, et al., Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to Drosophila Delta. Development. 1995 Aug;121(8):2407-18
J:84628 Six E, et al., The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7638-43
J:88030 Shimizu K, et al., Binding of Delta1, Jagged1, and Jagged2 to Notch2 rapidly induces cleavage, nuclear translocation, and hyperphosphorylation of Notch2. Mol Cell Biol. 2000 Sep;20(18):6913-22
J:90630 Hozumi K, et al., Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo. Nat Immunol. 2004 Jul;5(6):638-44
J:100814 Mizuhara E, et al., MAGI1 recruits Dll1 to cadherin-based adherens junctions and stabilizes it on the cell surface. J Biol Chem. 2005 Jul 15;280(28):26499-507
J:107414 Brooker R, et al., Notch ligands with contrasting functions: Jagged1 and Delta1 in the mouse inner ear. Development. 2006 Apr;133(7):1277-86
J:117595 Song R, et al., Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. J Biol Chem. 2006 Nov 24;281(47):36391-400
J:119082 Schuster-Gossler K, et al., Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):537-42
J:135515 Estrach S, et al., Role of the Notch ligand Delta1 in embryonic and adult mouse epidermis. J Invest Dermatol. 2008 Apr;128(4):825-32
J:143172 Kawaguchi D, et al., Selection of differentiating cells by different levels of delta-like 1 among neural precursor cells in the developing mouse telencephalon. Development. 2008 Dec;135(23):3849-58
J:146621 Tan JB, et al., Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches. Immunity. 2009 Feb;30(2):254-63
J:148902 Sorensen I, et al., DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. 2009 May 28;113(22):5680-8
J:149456 Rocha SF, et al., Dll1 and Dll4 function sequentially in the retina and pV2 domain of the spinal cord to regulate neurogenesis and create cell diversity. Dev Biol. 2009 Apr 1;328(1):54-65
J:150183 Rubio-Aliaga I, et al., Dll1 haploinsufficiency in adult mice leads to a complex phenotype affecting metabolic and immunological processes. PLoS One. 2009;4(6):e6054
J:156172 Marklund U, et al., Domain-specific control of neurogenesis achieved through patterned regulation of Notch ligand expression. Development. 2010 Feb;137(3):437-45
J:173235 Jin G, et al., MT1-MMP cleaves Dll1 to negatively regulate Notch signalling to maintain normal B-cell development. EMBO J. 2011 Jun 1;30(11):2281-93
J:177887 Stamataki D, et al., Delta1 expression, cell cycle exit, and commitment to a specific secretory fate coincide within a few hours in the mouse intestinal stem cell system. PLoS One. 2011;6(9):e24484
J:178999 Ahnfelt-Ronne J, et al., Ptf1a-mediated control of Dll1 reveals an alternative to the lateral inhibition mechanism. Development. 2012 Jan;139(1):33-45
J:179218 Grainger S, et al., Cdx regulates Dll1 in multiple lineages. Dev Biol. 2012 Jan 1;361(1):1-11
J:180704 Zhang L, et al., Delta-like 1-Lysine613 regulates notch signaling. Biochim Biophys Acta. 2011 Dec;1813(12):2036-43
J:184814 Horn S, et al., Mind bomb 1 is required for pancreatic beta-cell formation. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7356-61
J:188916 Brohl D, et al., Colonization of the satellite cell niche by skeletal muscle progenitor cells depends on Notch signals. Dev Cell. 2012 Sep 11;23(3):469-81
J:192694 Napp LC, et al., Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis. Circ Res. 2012 Feb 17;110(4):530-5
J:198632 Liu Z, et al., The Extracellular Domain of Notch2 Increases Its Cell-Surface Abundance and Ligand Responsiveness during Kidney Development. Dev Cell. 2013 Jun 24;25(6):585-98
J:198671 Nelson BR, et al., Dynamic interactions between intermediate neurogenic progenitors and radial glia in embryonic mouse neocortex: potential role in Dll1-Notch signaling. J Neurosci. 2013 May 22;33(21):9122-39
J:199717 Hiraoka Y, et al., Delta-like 1 regulates Bergmann glial monolayer formation during cerebellar development. Mol Brain. 2013;6:25
J:208850 Hatakeyama J, et al., Cadherin-based adhesions in the apical endfoot are required for active Notch signaling to control neurogenesis in vertebrates. Development. 2014 Apr;141(8):1671-82
J:213529 Braune EB, et al., S/T phosphorylation of DLL1 is required for full ligand activity in vitro but dispensable for DLL1 function in vivo during embryonic patterning and marginal zone B cell development. Mol Cell Biol. 2014 Apr;34(7):1221-33
J:216287 Czajkowski MT, et al., Divergent and conserved roles of Dll1 signaling in development of craniofacial and trunk muscle. Dev Biol. 2014 Nov 15;395(2):307-16
J:220446 Pellegrinet L, et al., Dll1- and dll4-mediated notch signaling are required for homeostasis of intestinal stem cells. Gastroenterology. 2011 Apr;140(4):1230-1240.e1-7
J:224724 Kawaguchi D, et al., Dll1 maintains quiescence of adult neural stem cells and segregates asymmetrically during mitosis. Nat Commun. 2013;4:1880
J:224738 Heuss SF, et al., The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11212-7
J:224861 Preusse K, et al., Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. PLoS Genet. 2015 Jun;11(6):e1005328
J:225411 Nehring LC, et al., The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface. J Biol Chem. 2005 May 27;280(21):20349-55
J:227382 Rullinkov G, et al., Neuralized-2: expression in human and rodents and interaction with Delta-like ligands. Biochem Biophys Res Commun. 2009 Nov 20;389(3):420-5

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MGI 6.14
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