Sequence Detail

ID/Version

Q61473 Q61472 Q62248 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcription factor SOX-17;

Provider

SWISS-PROT

Sequence

Polypeptide 419 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sox17	SRY (sex determining region Y)-box 17	116	152	3	24

Sequence references in MGI

J:33784 Kanai Y, et al., Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J Cell Biol. 1996 May;133(3):667-81
J:75946 Kanai-Azuma M, et al., Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002 May;129(10):2367-79
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113127 Matsui T, et al., Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice. J Cell Sci. 2006 Sep 1;119(Pt 17):3513-26
J:123050 Kim I, et al., Sox17 dependence distingushes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell. 2007 Aug 10;130(3):470-83
J:168158 Liu X, et al., Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promoter. Am J Physiol Lung Cell Mol Physiol. 2010 Nov;299(5):L694-710
J:168289 Palasingam P, et al., The structure of Sox17 bound to DNA reveals a conserved bending topology but selective protein interaction platforms. J Mol Biol. 2009 May 8;388(3):619-30
J:206194 Corada M, et al., Sox17 is indispensable for acquisition and maintenance of arterial identity. Nat Commun. 2013;4:2609