Sequence Detail

ID/Version

Q61382 Q8BHD9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=TNF receptor-associated factor 4; EC=2.3.2.27 {ECO:0000250|UniProtKB:Q9BUZ4};AltName: Full=Cysteine-rich motif associated to RING and Traf domains protein 1;

Provider

SWISS-PROT

Sequence

Polypeptide 470 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Traf4	TNF receptor associated factor 4	59	104	4	27

Sequence references in MGI

J:46644 Masson R, et al., Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. Mech Dev. 1998 Feb;71(1-2):187-91
J:68102 Grech A, et al., Complete structural characterisation of the mammalian and Drosophila TRAF genes: implications for TRAF evolution and the role of RING finger splice variants. Mol Immunol. 2000 Aug-Sep;37(12-13):721-34
J:74252 Shiels H, et al., TRAF4 deficiency leads to tracheal malformation with resulting alterations in air flow to the lungs. Am J Pathol. 2000 Aug;157(2):679-88
J:76067 Regnier CH, et al., Impaired neural tube closure, axial skeleton malformations, and tracheal ring disruption in TRAF4-deficient mice. Proc Natl Acad Sci U S A. 2002 Apr 16;99(8):5585-90
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:142780 Cherfils-Vicini J, et al., Characterization of immune functions in TRAF4-deficient mice. Immunology. 2008 Aug;124(4):562-74
J:163137 Abell AN, et al., MEKK4 is an effector of the embryonic TRAF4 for JNK activation. J Biol Chem. 2005 Oct 28;280(43):35793-6
J:196439 Chen BB, et al., A combinatorial F box protein directed pathway controls TRAF adaptor stability to regulate inflammation. Nat Immunol. 2013 May;14(5):470-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89