Sequence Detail

ID/Version

Q61337 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Bcl2-associated agonist of cell death; Short=BAD;AltName: Full=Bcl-2-binding component 6;AltName: Full=Bcl-xL/Bcl-2-associated death promoter;AltName: Full=Bcl2 antagonist of cell death;

Provider

SWISS-PROT

Sequence

Polypeptide 204 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Bad	BCL2-associated agonist of cell death	127	110	4	32

Sequence references in MGI

J:42326 Yang E, et al., Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death. Cell. 1995 Jan 27;80(2):285-91
J:74669 Dramsi S, et al., Identification of a Novel Phosphorylation Site, Ser-170, as a Regulator of Bad Pro-apoptotic Activity. J Biol Chem. 2002 Feb 22;277(8):6399-405
J:86593 Yan B, et al., The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem. 2003 Nov 14;278(46):45358-67
J:107746 Nitta T, et al., IAN family critically regulates survival and development of T lymphocytes. PLoS Biol. 2006 Apr;4(4):e103
J:161036 Harada H, et al., p70S6 kinase signals cell survival as well as growth, inactivating the pro-apoptotic molecule BAD. Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9666-70
J:203396 Torii S, et al., Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. Cell Death Differ. 2011 Nov;18(11):1711-25
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89