Sequence Detail

ID/Version

Q61214 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Dual specificity tyrosine-phosphorylation-regulated kinase 1A; EC=2.7.11.23 {ECO:0000250|UniProtKB:Q13627}; EC=2.7.12.1 {ECO:0000269|PubMed:20167603};AltName: Full=Dual specificity YAK1-related kinase;AltName: Full=MP86;AltNa

Provider

SWISS-PROT

Sequence

Polypeptide 763 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dyrk1a	dual-specificity tyrosine phosphorylation regulated kinase 1a	103	119	4	131

Sequence references in MGI

J:37711 Song WJ, et al., Isolation of human and murine homologues of the Drosophila minibrain gene: human homologue maps to 21q22.2 in the Down syndrome critical region. Genomics. 1996 Dec 15;38(3):331-9
J:38630 Song WJ, et al., The murine Dyrk protein maps to chromosome 16, localizes to the nucleus, and can form multimers. Biochem Biophys Res Commun. 1997 Feb 24;231(3):640-4
J:91599 Sitz JH, et al., Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Mol Cell Biol. 2004 Jul;24(13):5821-34
J:144655 Sitz JH, et al., The Down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4. Neuroscience. 2008 Dec 2;157(3):596-605
J:161722 Kurabayashi N, et al., DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping. Mol Cell Biol. 2010 Apr;30(7):1757-68
J:165940 Guo X, et al., DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1. J Biol Chem. 2010 Apr 23;285(17):13223-32
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89