Sequence Detail

ID/Version

Q61210 Q3T9Q7 O89074 Q80YE8 Q91VL3 Q80YE9 (UniProt | EBI)

Last sequence update: 2003-08-29
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Rho guanine nucleotide exchange factor 1;AltName: Full=Lbc's second cousin;AltName: Full=Lymphoid blast crisis-like 2;

Provider

SWISS-PROT

Sequence

Polypeptide 920 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Arhgef1	Rho guanine nucleotide exchange factor 1	24	103	4	19

Sequence references in MGI

J:34523 Whitehead IP, et al., Expression cloning of lsc, a novel oncogene with structural similarities to the Dbl family of guanine nucleotide exchange factors. J Biol Chem. 1996 Aug 2;271(31):18643-50
J:62630 Chu CC, et al., Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis. Mol Immunol. 1998 Jun;35(8):487-502
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118143 Kostenko EV, et al., Ccpg1, a novel scaffold protein that regulates the activity of the Rho guanine nucleotide exchange factor Dbs. Mol Cell Biol. 2006 Dec;26(23):8964-75
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:157074 Guilluy C, et al., The Rho exchange factor Arhgef1 mediates the effects of angiotensin II on vascular tone and blood pressure. Nat Med. 2010 Feb;16(2):183-90
J:217491 Muppidi JR, et al., Loss of signalling via Galpha13 in germinal centre B-cell-derived lymphoma. Nature. 2014 Dec 11;516(7530):254-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89