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Sequence Detail
Q61188 Q9R090 Q99L74 (UniProt | EBI) Last sequence update: 2011-07-27
Last annotation update: 2020-08-12
from provider
RecName: Full=Histone-lysine N-methyltransferase EZH2 {ECO:0000305}; EC= {ECO:0000250|UniProtKB:Q15910};AltName: Full=ENX-1;AltName: Full=Enhancer of zeste homolog 2;
Polypeptide 746 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Ezh2 enhancer of zeste 2 polycomb repressive complex 2 subunit 104 106 9 54
Sequence references in MGI J:32835 Hobert O, et al., Isolation and developmental expression analysis of Enx-1, a novel mouse Polycomb group gene. Mech Dev. 1996 Apr;55(2):171-84
J:50304 Laible G, et al., The murine polycomb-group genes Ezh1 and Ezh2 map close to Hox gene clusters on mouse chromosomes 11 and 6. Mamm Genome. 1999 Mar;10(3):311-4
J:69977 O'Carroll D, et al., The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol. 2001 Jul;21(13):4330-6
J:82788 Plath K, et al., Role of histone H3 lysine 27 methylation in X inactivation. Science. 2003 Apr 4;300(5616):131-5
J:90454 Mak W, et al., Reactivation of the paternal X chromosome in early mouse embryos. Science. 2004 Jan 30;303(5658):666-9
J:93445 Caretti G, et al., The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation. Genes Dev. 2004 Dec 1;18(21):2627-38
J:94241 Umlauf D, et al., Imprinting along the Kcnq1 domain on mouse chromosome 7 involves repressive histone methylation and recruitment of Polycomb group complexes. Nat Genet. 2004 Dec;36(12):1296-300
J:116444 Etchegaray JP, et al., The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem. 2006 Jul 28;281(30):21209-15
J:121147 Kim SY, et al., Developmental regulation of Eed complex composition governs a switch in global histone modification in brain. J Biol Chem. 2007 Mar 30;282(13):9962-72
J:129406 Kalantry S, et al., The Polycomb group protein Eed protects the inactive X-chromosome from differentiation-induced reactivation. Nat Cell Biol. 2006 Feb;8(2):195-202
J:142192 Margueron R, et al., Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms. Mol Cell. 2008 Nov 21;32(4):503-18
J:142193 Shen X, et al., EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency. Mol Cell. 2008 Nov 21;32(4):491-502
J:157068 Walker E, et al., Polycomb-like 2 associates with PRC2 and regulates transcriptional networks during mouse embryonic stem cell self-renewal and differentiation. Cell Stem Cell. 2010 Feb 5;6(2):153-66
J:200345 Denisenko O, et al., Point mutations in the WD40 domain of Eed block its interaction with Ezh2. Mol Cell Biol. 1998 Oct;18(10):5634-42
J:201058 Nguyen KD, et al., Circadian gene Bmal1 regulates diurnal oscillations of Ly6C(hi) inflammatory monocytes. Science. 2013 Sep 27;341(6153):1483-8
J:206847 Neri F, et al., Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs. Cell. 2013 Sep 26;155(1):121-34
J:247419 Han Z, et al., Structural basis of EZH2 recognition by EED. Structure. 2007 Oct;15(10):1306-15
J:281161 Ragazzini R, et al., EZHIP constrains Polycomb Repressive Complex 2 activity in germ cells. Nat Commun. 2019 Aug 26;10(1):3858
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory