Sequence Detail

ID/Version

Q61183 Q61208 Q8K4X2 Q61209 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Poly(A) polymerase alpha; Short=PAP-alpha; EC=2.7.7.19 {ECO:0000269|PubMed:18084034};AltName: Full=Polynucleotide adenylyltransferase;

Provider

SWISS-PROT

Sequence

Polypeptide 739 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Papola	poly (A) polymerase alpha	35	99	3	194

Sequence references in MGI

J:33284 Zhao W, et al., Complex alternative RNA processing generates an unexpected diversity of poly(A) polymerase isoforms. Mol Cell Biol. 1996 May;16(5):2378-86
J:80657 Kashiwabara S, et al., Regulation of spermatogenesis by testis-specific, cytoplasmic poly(A) polymerase TPAP. Science. 2002 Dec 6;298(5600):1999-2002
J:149256 Kiefer H, et al., Inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) associates with components of the mRNA 3' processing machinery in a phosphorylation-dependent manner and inhibits polyadenylation. J Biol Chem. 2009 Apr 17;284(16):10694-705
J:172165 Lee SH, et al., ERK is a novel regulatory kinase for poly(A) polymerase. Nucleic Acids Res. 2008 Feb;36(3):803-13
J:255342 Kim H, et al., Interaction of poly(A) polymerase with the 25-kDa subunit of cleavage factor I. Biochem Biophys Res Commun. 2001 Nov 30;289(2):513-8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89