Sequence Detail

ID/Version

Q61180 Q9WU37 (UniProt | EBI)

Last sequence update: 2000-12-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Epithelial sodium channel subunit alpha {ECO:0000305|PubMed:10409305}; Short=Alpha-ENaC {ECO:0000303|PubMed:10409305}; Short=Epithelial Na(+) channel subunit alpha {ECO:0000303|PubMed:10409305};AltName: Full=Alpha-NaCH;AltNam

Provider

SWISS-PROT

Sequence

Polypeptide 699 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Scnn1a	sodium channel, nonvoltage-gated 1 alpha	109	113	2	8

Sequence references in MGI

J:31762 Hummler E, et al., Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice. Nat Genet. 1996 Mar;12(3):325-8
J:42864 Dagenais A, et al., The alpha subunit of the epithelial sodium channel in the mouse: developmental regulation of its expression. Pediatr Res. 1997 Sep;42(3):327-34
J:43583 Hummler E, et al., A mouse model for the renal salt-wasting syndrome pseudohypoaldosteronism. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11710-5
J:56566 Ahn YJ, et al., Cloning and functional expression of the mouse epithelial sodium channel. Am J Physiol. 1999 Jul;277(1 Pt 2):F121-9
J:226737 Malsure S, et al., Colon-specific deletion of epithelial sodium channel causes sodium loss and aldosterone resistance. J Am Soc Nephrol. 2014 Jul;25(7):1453-64
J:333673 Fotia AB, et al., Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem. 2004 Jul 9;279(28):28930-5