Sequence Detail

ID/Version

Q61164 (UniProt | EBI)

Last sequence update: 2003-04-23
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Transcriptional repressor CTCF;AltName: Full=11-zinc finger protein;AltName: Full=CCCTC-binding factor;AltName: Full=CTCFL paralog;

Provider

SWISS-PROT

Sequence

Polypeptide 736 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ctcf	CCCTC-binding factor	96	117	3	152

Sequence references in MGI

J:33964 Filippova GN, et al., An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol Cell Biol. 1996 Jun;16(6):2802-13
J:73834 Chao W, et al., CTCF, a candidate trans-acting factor for X-inactivation choice. Science. 2002 Jan 11;295(5553):345-7
J:95807 Fillipova GN, et al., Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. Dev Cell. 2005 Jan;8(1):31-42
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:112158 Splinter E, et al., CTCF mediates long-range chromatin looping and local histone modification in the beta-globin locus. Genes Dev. 2006 Sep 1;20(17):2349-54
J:112733 Ishihara K, et al., CTCF-dependent chromatin insulator is linked to epigenetic remodeling. Mol Cell. 2006 Sep 1;23(5):733-42
J:130305 Xu N, et al., Evidence that homologous X-chromosome pairing requires transcription and Ctcf protein. Nat Genet. 2007 Nov;39(11):1390-6
J:150910 Wan LB, et al., Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. Development. 2008 Aug;135(16):2729-38
J:235308 Yu NK, et al., A transducible nuclear/nucleolar protein, mLLP, regulates neuronal morphogenesis and synaptic transmission. Sci Rep. 2016;6:22892
J:343119 Hsu SC, et al., The BET Protein BRD2 Cooperates with CTCF to Enforce Transcriptional and Architectural Boundaries. Mol Cell. 2017 Apr 6;66(1):102-116.e7