Sequence Detail

ID/Version

Q61097 Q61648 Q78DX8 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Kinase suppressor of Ras 1; Short=mKSR1; EC=2.7.11.1 {ECO:0000269|PubMed:21441104};AltName: Full=Protein Hb;

Provider

SWISS-PROT

Sequence

Polypeptide 873 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ksr1	kinase suppressor of ras 1	60	100	4	18

Sequence references in MGI

J:25181 Nehls M, et al., YAC/P1 contigs defining the location of 56 microsatellite markers and several genes across a 3.4-cM interval on mouse chromosome 11. Mamm Genome. 1995 May;6(5):321-31
J:30250 Therrien M, et al., KSR, a novel protein kinase required for RAS signal transduction [see comments]. Cell. 1995 Dec 15;83(6):879-88
J:63239 Muller J, et al., Identification of B-KSR1, a novel brain-specific isoform of KSR1 that functions in neuronal signaling. Mol Cell Biol. 2000 Aug;20(15):5529-39
J:230400 Stewart S, et al., Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol. 1999 Aug;19(8):5523-34
J:231274 Smith FD, et al., AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade. Nat Cell Biol. 2010 Dec;12(12):1242-9
J:277858 Hu J, et al., Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6067-72
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:326246 Muller J, et al., Functional analysis of C-TAK1 substrate binding and identification of PKP2 as a new C-TAK1 substrate. EMBO J. 2003 Sep 1;22(17):4431-42