Sequence Detail

ID/Version

Q61086 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Frizzled-3; Short=Fz-3; Short=mFz3;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 666 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fzd3	frizzled class receptor 3	63	141	4	13

Sequence references in MGI

J:37068 Wang Y, et al., A large family of putative transmembrane receptors homologous to the product of the Drosophila tissue polarity gene frizzled. J Biol Chem. 1996 Feb 23;271(8):4468-76
J:69980 Hung BS, et al., Characterization of mouse Frizzled-3 expression in hair follicle development and identification of the human homolog in keratinocytes. J Invest Dermatol. 2001 Jun;116(6):940-6
J:79213 Wang Y, et al., Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci. 2002 Oct 1;22(19):8563-73
J:86902 Lyuksyutova AI, et al., Anterior-posterior guidance of commissural axons by Wnt-frizzled signaling. Science. 2003 Dec 12;302(5652):1984-8
J:104270 Wang Y, et al., Axonal growth and guidance defects in Frizzled3 knock-out mice: a comparison of diffusion tensor magnetic resonance imaging, neurofilament staining, and genetically directed cell labeling. J Neurosci. 2006 Jan 11;26(2):355-64
J:105752 Wang Y, et al., The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells. J Neurosci. 2006 Feb 22;26(8):2147-56
J:108647 Montcouquiol M, et al., Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci. 2006 May 10;26(19):5265-75
J:169444 Armstrong A, et al., Frizzled3 Is Required for Neurogenesis and Target Innervation during Sympathetic Nervous System Development. J Neurosci. 2011 Feb 16;31(7):2371-81
J:207894 Hua ZL, et al., Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons. Elife. 2013;2:e01482
J:212111 Hua ZL, et al., Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E3005-14