Sequence Detail

ID/Version

Q61083 (UniProt | EBI)

Last sequence update: 2005-03-29
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Mitogen-activated protein kinase kinase kinase 2; EC=2.7.11.25;AltName: Full=MAPK/ERK kinase kinase 2; Short=MEK kinase 2; Short=MEKK 2;

Provider

SWISS-PROT

Sequence

Polypeptide 619 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Map3k2	mitogen-activated protein kinase kinase kinase 2	15	100	3	22

Sequence references in MGI

J:31860 Blank JL, et al., Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. Regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J Biol Chem. 1996 Mar 8;271(10):5361-8
J:63925 Sun W, et al., MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase. J Biol Chem. 2000 Aug 11;275(32):24421-8
J:82875 Huang J, et al., Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity. Biochem Biophys Res Commun. 2003 Apr 4;303(2):532-40
J:85661 Nakamura K, et al., PB1 domains of MEKK2 and MEKK3 interact with the MEK5 PB1 domain for activation of the ERK5 pathway. J Biol Chem. 2003 Sep 26;278(39):36989-92
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89