Sequence Detail

ID/Version

Q61045 O70284 P70183 (UniProt | EBI)

Last sequence update: 1999-07-15
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Single-minded homolog 1; Short=mSIM1;

Provider

SWISS-PROT

Sequence

Polypeptide 765 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Sim1	single-minded family bHLH transcription factor 1	25	149	4	14

Sequence references in MGI

J:31897 Fan CM, et al., Expression patterns of two murine homologs of Drosophila single-minded suggest possible roles in embryonic patterning and in the pathogenesis of Down syndrome. Mol Cell Neurosci. 1996 Jan;7(1):1-16
J:35345 Ema M, et al., Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol Cell Biol. 1996 Oct;16(10):5865-75
J:38688 Probst MR, et al., Two murine homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator protein. J Biol Chem. 1997 Feb 14;272(7):4451-7
J:41129 Chrast R, et al., Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region [letter]. Genome Res. 1997 Jun;7(6):615-24
J:238807 Wu D, et al., NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors. Elife. 2016 Oct 26;5:e18790