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Sequence Detail
Q61039 Q61100 (UniProt | EBI) Last sequence update: 2004-05-10
Last annotation update: 2018-03-28
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RecName: Full=Heart- and neural crest derivatives-expressed protein 2;AltName: Full=Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; Short=dHAND;AltName: Full=Helix-loop-helix transcription factor express
Polypeptide 217 aa
For this sequence
Organism mouse
See UniProt | EBI for source
Annotated genes and markers Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.
Type Symbol Name GO Terms Expression
Orthologs Phenotypic
Gene Hand2 heart and neural crest derivatives expressed 2 80 56 8 22
Sequence references in MGI J:28009 Cross JC, et al., Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development. 1995 Aug;121(8):2513-23
J:35033 Srivastava D, et al., A subclass of bHLH proteins required for cardiac morphogenesis. Science. 1995 Dec 22;270(5244):1995-9
J:40768 Srivastava D, et al., Regulation of cardiac mesodermal and neural crest development by the bHLH transcription factor, dHAND [see comments] [published erratum appears in Nat Genet 1997 Aug;16(4):410]. Nat Genet. 1997 Jun;16(2):154-60
J:49658 Thomas T, et al., A signaling cascade involving endothelin-1, dHAND and msx1 regulates development of neural-crest-derived branchial arch mesenchyme. Development. 1998 Aug;125(16):3005-14
J:61522 Fernandez-Teran M, et al., Role of dHAND in the anterior-posterior polarization of the limb bud: implications for the sonic hedgehog pathway. Development. 2000 May;127(10):2133-42
J:62028 Charite J, et al., The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development. 2000 Jun;127(11):2461-70
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:113904 Firulli BA, et al., The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function. J Biol Chem. 2000 Oct 27;275(43):33567-73

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last database update
MGI 6.11
The Jackson Laboratory