Sequence Detail

ID/Version

Q61037 P97723 P97724 P97727 P97725 Q9WUF6 Q61007 Q61008 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Tuberin {ECO:0000305};AltName: Full=Tuberous sclerosis 2 protein homolog {ECO:0000303|PubMed:8777431};

Provider

SWISS-PROT

Sequence

Polypeptide 1814 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Tsc2	TSC complex subunit 2	126	121	3	23

Sequence references in MGI

J:32010 Olsson PG, et al., Expression and differential splicing of the mouse TSC2 homolog. Mamm Genome. 1996 Mar;7(3):212-5
J:33186 Kim KK, et al., Cloning, developmental expression, and evidence for alternative splicing of the murine tuberous sclerosis (TSC2) gene product. Cell Mol Biol Res. 1995;41(6):515-26
J:50110 Sarker AH, et al., Cloning and characterization of a mouse homologue (mNthl1) of Escherichia coli endonuclease III. J Mol Biol. 1998 Oct 2;282(4):761-74
J:58668 Kleymenova EV, et al., Genetic variants of the tuberous sclerosis 2 tumour suppressor gene in mouse t haplotypes. Genet Res. 1999 Oct;74(2):139-44
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:338163 Garami A, et al., Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell. 2003 Jun;11(6):1457-66
J:338164 Menon S, et al., Spatial control of the TSC complex integrates insulin and nutrient regulation of mTORC1 at the lysosome. Cell. 2014 Feb 13;156(4):771-85