Sequence Detail

ID/Version

Q61036 Q8K1R6 Q8K1R5 O88645 (UniProt | EBI)

Last sequence update: 2004-05-10
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Serine/threonine-protein kinase PAK 3; EC=2.7.11.1;AltName: Full=Beta-PAK;AltName: Full=CDC42/RAC effector kinase PAK-B;AltName: Full=p21-activated kinase 3; Short=PAK-3;

Provider

SWISS-PROT

Sequence

Polypeptide 559 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pak3	p21 (RAC1) activated kinase 3	55	115	2	10

Sequence references in MGI

J:29051 Bagrodia S, et al., Identification of a mouse p21Cdc42/Rac activated kinase [published erratum appears in J Biol Chem 1996 Jan 12;271(2):1250]. J Biol Chem. 1995 Sep 29;270(39):22731-7
J:55429 Burbelo PD, et al., Cloning, central nervous system expression and chromosomal mapping of the mouse PAK-1 and PAK-3 genes. Gene. 1999 May 31;232(2):209-15
J:81686 Rousseau V, et al., A New Constitutively Active Brain PAK3 Isoform Displays Modified Specificities toward Rac and Cdc42 GTPases. J Biol Chem. 2003 Feb 7;278(6):3912-20
J:98630 Zhang H, et al., A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis and synapse formation through MLC. J Neurosci. 2005 Mar 30;25(13):3379-88
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:99811 Meng J, et al., Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci. 2005 Jul 13;25(28):6641-50
J:124615 Kreis P, et al., The p21-activated kinase 3 implicated in mental retardation regulates spine morphogenesis through a Cdc42-dependent pathway. J Biol Chem. 2007 Jul 20;282(29):21497-506
J:169422 Huang W, et al., p21-Activated kinases 1 and 3 control brain size through coordinating neuronal complexity and synaptic properties. Mol Cell Biol. 2011 Feb;31(3):388-403
J:239194 Jaudon F, et al., The RhoGEF DOCK10 is essential for dendritic spine morphogenesis. Mol Biol Cell. 2015 Jun 01;26(11):2112-27
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89