Sequence Detail

ID/Version

Q61026 O09001 P97759 E9QMH9 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Nuclear receptor coactivator 2; Short=NCoA-2;AltName: Full=Glucocorticoid receptor-interacting protein 1 {ECO:0000303|PubMed:9111344}; Short=GRIP-1 {ECO:0000303|PubMed:9111344};AltName: Full=Steroid receptor coactivator 2;

Provider

SWISS-PROT

Sequence

Polypeptide 1462 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ncoa2	nuclear receptor coactivator 2	101	115	3	39

Sequence references in MGI

J:33918 Hong H, et al., GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4948-52
J:42181 Torchia J, et al., The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function [see comments]. Nature. 1997 Jun 12;387(6634):677-84
J:64957 Chen D, et al., Regulation of transcription by a protein methyltransferase. Science. 1999 Jun 25;284(5423):2174-7
J:80975 Picard F, et al., SRC-1 and TIF2 Control Energy Balance between White and Brown Adipose Tissues. Cell. 2002 Dec 27;111(7):931-41
J:116733 Xie H, et al., RORgammat recruits steroid receptor coactivators to ensure thymocyte survival. J Immunol. 2005 Sep 15;175(6):3800-9
J:142097 Chopra AR, et al., Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28;322(5906):1395-9
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:159077 Kino T, et al., Tumor necrosis factor alpha receptor- and Fas-associated FLASH inhibit transcriptional activity of the glucocorticoid receptor by binding to and interfering with its interaction with p160 type nuclear receptor coactivators. J Biol Chem. 2003 Jan 31;278(5):3023-9
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:215957 Stashi E, et al., SRC-2 is an essential coactivator for orchestrating metabolism and circadian rhythm. Cell Rep. 2014 Feb 27;6(4):633-45
J:222684 Wansa KD, et al., The AF-1 domain of the orphan nuclear receptor NOR-1 mediates trans-activation, coactivator recruitment, and activation by the purine anti-metabolite 6-mercaptopurine. J Biol Chem. 2003 Jul 4;278(27):24776-90
J:288674 Naiman S, et al., SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARalpha. Cell Rep. 2019 Dec 17;29(12):4127-4143.e8
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:306378 Guo A, et al., Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan;13(1):372-87