Sequence Detail

ID/Version

Q61006 Q61987 Q61988 Q61005 (UniProt | EBI)

Last sequence update: 1996-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Muscle, skeletal receptor tyrosine-protein kinase; EC=2.7.10.1;AltName: Full=Muscle-specific tyrosine-protein kinase receptor; Short=MuSK; Short=Muscle-specific kinase receptor;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 868 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Musk	muscle, skeletal, receptor tyrosine kinase	96	110	3	11

Sequence references in MGI

J:27415 Ganju P, et al., Cloning and developmental expression of Nsk2, a novel receptor tyrosine kinase implicated in skeletal myogenesis. Oncogene. 1995 Jul 20;11(2):281-90
J:33132 DeChiara TM, et al., The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo. Cell. 1996 May 17;85(4):501-12
J:33184 Glass DJ, et al., Agrin acts via a MuSK receptor complex. Cell. 1996 May 17;85(4):513-23
J:78399 Luo ZG, et al., Regulation of AChR clustering by Dishevelled interacting with MuSK and PAK1. Neuron. 2002 Aug 1;35(3):489-505
J:83827 Lin W, et al., Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse. Nature. 2001 Apr 26;410(6832):1057-64
J:86639 Luo ZG, et al., Implication of geranylgeranyltransferase I in synapse formation. Neuron. 2003 Nov 13;40(4):703-17
J:87379 Bromann PA, et al., A putative ariadne-like E3 ubiquitin ligase (PAUL) that interacts with the muscle-specific kinase (MuSK). Gene Expr Patterns. 2004 Jan;4(1):77-84
J:92775 Mittaud P, et al., A single pulse of agrin triggers a pathway that acts to cluster acetylcholine receptors. Mol Cell Biol. 2004 Sep;24(18):7841-54
J:110011 Okada K, et al., The muscle protein Dok-7 is essential for neuromuscular synaptogenesis. Science. 2006 Jun 23;312(5781):1802-5
J:110237 Cheusova T, et al., Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular junction. Genes Dev. 2006 Jul 1;20(13):1800-16
J:134925 Lu Z, et al., Regulation of synaptic growth and maturation by a synapse-associated E3 ubiquitin ligase at the neuromuscular junction. J Cell Biol. 2007 Jun 18;177(6):1077-89
J:145446 Kim N, et al., Lrp4 is a receptor for Agrin and forms a complex with MuSK. Cell. 2008 Oct 17;135(2):334-42
J:145549 Linnoila J, et al., A mammalian homolog of Drosophila tumorous imaginal discs, Tid1, mediates agrin signaling at the neuromuscular junction. Neuron. 2008 Nov 26;60(4):625-41
J:163004 Bergamin E, et al., The cytoplasmic adaptor protein Dok7 activates the receptor tyrosine kinase MuSK via dimerization. Mol Cell. 2010 Jul 9;39(1):100-9
J:196095 Zhu D, et al., Muscle-specific receptor tyrosine kinase endocytosis in acetylcholine receptor clustering in response to agrin. J Neurosci. 2008 Feb 13;28(7):1688-96