Sequence Detail

ID/Version

Q60991 Q9CZ39 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Cytochrome P450 7B1;AltName: Full=24-hydroxycholesterol 7-alpha-hydroxylase {ECO:0000305|PubMed:11067870}; EC=1.14.14.26 {ECO:0000269|PubMed:11067870};AltName: Full=25/26-hydroxycholesterol 7-alpha-hydroxylase {ECO:0000305|PubMed:929

Provider

SWISS-PROT

Sequence

Polypeptide 507 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	36	111	3	12

Sequence references in MGI

J:30123 Stapleton G, et al., A novel cytochrome P450 expressed primarily in brain. J Biol Chem. 1995 Dec 15;270(50):29739-45
J:40332 Rose KA, et al., Cyp7b, a novel brain cytochrome P450, catalyzes the synthesis of neurosteroids 7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4925-30
J:43019 Schwarz M, et al., Identification and characterization of a mouse oxysterol 7alpha-hydroxylase cDNA. J Biol Chem. 1997 Sep 19;272(38):23995-4001
J:62589 Li-Hawkins J, et al., Expression cloning of an oxysterol 7alpha-hydroxylase selective for 24-hydroxycholesterol. J Biol Chem. 2000 Jun 2;275(22):16543-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111675 Schwarz M, et al., The bile acid synthetic gene 3beta-hydroxy-Delta(5)-C(27)-steroid oxidoreductase is mutated in progressive intrahepatic cholestasis. J Clin Invest. 2000 Nov;106(9):1175-84
J:188276 Yi T, et al., Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses. Immunity. 2012 Sep 21;37(3):535-48