Sequence Detail

ID/Version

Q60953 Q8CEJ1 Q8VCC4 (UniProt | EBI)

Last sequence update: 2007-05-29
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Protein PML;

Provider

SWISS-PROT

Sequence

Polypeptide 885 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Pml	promyelocytic leukemia	182	109	2	89

Sequence references in MGI

J:29383 Goddard AD, et al., Cloning of the murine homolog of the leukemia-associated PML gene. Mamm Genome. 1995 Oct;6(10):732-7
J:46381 Wang ZG, et al., Role of PML in cell growth and the retinoic acid pathway. Science. 1998 Mar 6;279(5356):1547-51
J:50588 Wang ZG, et al., PML is essential for multiple apoptotic pathways [see comments]. Nat Genet. 1998 Nov;20(3):266-72
J:92664 Lin HK, et al., Cytoplasmic PML function in TGF-beta signalling. Nature. 2004 Sep 9;431(7005):205-11
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:111744 Bernardi R, et al., PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature. 2006 Aug 17;442(7104):779-85
J:118799 Cohen N, et al., PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. EMBO J. 2001 Aug 15;20(16):4547-59
J:123220 Zhong S, et al., Role of SUMO-1-modified PML in nuclear body formation. Blood. 2000 May 1;95(9):2748-52
J:146180 Regad T, et al., The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat Neurosci. 2009 Feb;12(2):132-40
J:166717 Giorgi C, et al., PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science. 2010 Nov 26;330(6008):1247-51
J:169789 Bernardi R, et al., PML regulates p53 stability by sequestering Mdm2 to the nucleolus. Nat Cell Biol. 2004 Jul;6(7):665-72
J:172072 Khalfin-Rabinovich Y, et al., PML is a key component for the differentiation of myeloid progenitor cells to macrophages. Int Immunol. 2011 Apr;23(4):287-96
J:181918 Miki T, et al., PML regulates PER2 nuclear localization and circadian function. EMBO J. 2012;31(6):1427-39
J:191430 Carracedo A, et al., A metabolic prosurvival role for PML in breast cancer. J Clin Invest. 2012 Sep 4;122(9):3088-100
J:204028 Erker Y, et al., Arkadia, a novel SUMO-targeted ubiquitin ligase involved in PML degradation. Mol Cell Biol. 2013 Jun;33(11):2163-77
J:206771 Butler K, et al., Impaired cognitive function and reduced anxiety-related behavior in a promyelocytic leukemia (PML) tumor suppressor protein-deficient mouse. Genes Brain Behav. 2013 Mar;12(2):189-202
J:244192 Lunardi A, et al., A Role for PML in Innate Immunity. Genes Cancer. 2011 Jan;2(1):10-9
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89