Sequence Detail

ID/Version

Q60876 Q3TDS8 Q9CZ40 (UniProt | EBI)

Last sequence update: 2007-01-23
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Eukaryotic translation initiation factor 4E-binding protein 1; Short=4E-BP1; Short=eIF4E-binding protein 1;AltName: Full=Phosphorylated heat- and acid-stable protein regulated by insulin 1; Short=PHAS-I;

Provider

SWISS-PROT

Sequence

Polypeptide 117 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Eif4ebp1	eukaryotic translation initiation factor 4E binding protein 1	36	111	3	48

Sequence references in MGI

J:27764 Lin TA, et al., Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. J Biol Chem. 1995 Aug 4;270(31):18531-8
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:118038 Le Bacquer O, et al., Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. J Clin Invest. 2007 Feb;117(2):387-96
J:203767 Hartman NW, et al., mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo. Cell Rep. 2013 Oct 31;5(2):433-44
J:243471 Cattin ME, et al., Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. J Biol Chem. 2015 Oct 30;290(44):26699-714
J:243830 Olson KE, et al., Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2. Immunology. 2009 Sep;128(1 Suppl):e376-84
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89