Sequence Detail

ID/Version

Q60857 Q5NCR6 O35241 (UniProt | EBI)

Last sequence update: 2011-07-27
Last annotation update: 2024-03-27

Sequence description from provider

RecName: Full=Sodium-dependent serotonin transporter {ECO:0000305}; Short=SERT {ECO:0000303|PubMed:29038237};AltName: Full=5HT transporter; Short=5HTT;AltName: Full=Solute carrier family 6 member 4;

Provider

SWISS-PROT

Sequence

Polypeptide 630 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Slc6a4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	91	125	4	28

Sequence references in MGI

J:11901 Gregor P, et al., Murine serotonin transporter: sequence and localization to chromosome 11. Mamm Genome. 1993;4(5):283-4
J:37663 Chang AS, et al., Cloning and expression of the mouse serotonin transporter. Brain Res Mol Brain Res. 1996 Dec 31;43(1-2):185-92
J:38861 Bengel D, et al., Gene structure and 5'-flanking regulatory region of the murine serotonin transporter. Brain Res Mol Brain Res. 1997 Mar;44(2):286-92
J:76020 Bengel D, et al., Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ('Ecstasy') in serotonin transporter-deficient mice. Mol Pharmacol. 1998 Apr;53(4):649-55
J:121594 Chanrion B, et al., Physical interaction between the serotonin transporter and neuronal nitric oxide synthase underlies reciprocal modulation of their activity. Proc Natl Acad Sci U S A. 2007 May 8;104(19):8119-24
J:135834 Carneiro AM, et al., Interactions between integrin alphaIIbbeta3 and the serotonin transporter regulate serotonin transport and platelet aggregation in mice and humans. J Clin Invest. 2008 Apr;118(4):1544-52
J:164404 Garcia-Frigola C, et al., Zic2 regulates the expression of Sert to modulate eye-specific refinement at the visual targets. EMBO J. 2010 Sep 15;29(18):3170-83
J:222808 Chen X, et al., Disruption of Transient Serotonin Accumulation by Non-Serotonin-Producing Neurons Impairs Cortical Map Development. Cell Rep. 2015 Jan 14;
J:237081 Margolis KG, et al., Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function. J Clin Invest. 2016 Jun 01;126(6):2221-35
J:244183 Ushijima K, et al., Role of activating transcription factor-4 in 24-hour rhythm of serotonin transporter expression in the mouse midbrain. Mol Pharmacol. 2012 Aug;82(2):264-70
J:250837 Dohn MR, et al., The Gain-of-Function Integrin beta3 Pro33 Variant Alters the Serotonin System in the Mouse Brain. J Neurosci. 2017 Nov 15;37(46):11271-11284