Sequence Detail

ID/Version

Q60855 Q8CD90 Q3U0J3 (UniProt | EBI)

Last sequence update: 1997-11-01
Last annotation update: 2025-02-05

Sequence description from provider

RecName: Full=Receptor-interacting serine/threonine-protein kinase 1 {ECO:0000305}; EC=2.7.11.1 {ECO:0000269|PubMed:28701375, ECO:0000269|PubMed:29440439, ECO:0000269|PubMed:30988283, ECO:0000269|PubMed:31511692, ECO:0000269|PubMed:31519886, ECO:0

Provider

SWISS-PROT

Sequence

Polypeptide 656 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Ripk1	receptor (TNFRSF)-interacting serine-threonine kinase 1	203	113	3	38

Sequence references in MGI

J:43377 Stanger BZ, et al., RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell. 1995 May 19;81(4):513-23
J:82757 Hur GM, et al., The death domain kinase RIP has an essential role in DNA damage-induced NF-kappa B activation. Genes Dev. 2003 Apr 1;17(7):873-82
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:131849 Iha H, et al., Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation. EMBO J. 2008 Feb 20;27(4):629-41
J:157332 Rebsamen M, et al., DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 2009 Aug;10(8):916-22
J:209137 Newton K, et al., Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis. Science. 2014 Mar 21;343(6177):1357-60
J:214393 Dillon CP, et al., RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3. Cell. 2014 May 22;157(5):1189-202
J:214394 Rickard JA, et al., RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis. Cell. 2014 May 22;157(5):1175-88
J:219499 Weinlich R, et al., The two faces of receptor interacting protein kinase-1. Mol Cell. 2014 Nov 20;56(4):469-80
J:242990 Newton K, et al., RIPK1 inhibits ZBP1-driven necroptosis during development. Nature. 2016 Dec 01;540(7631):129-133
J:242991 Lin J, et al., RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature. 2016 Dec 01;540(7631):124-128
J:244164 Wei R, et al., SPATA2 regulates the activation of RIPK1 by modulating linear ubiquitination. Genes Dev. 2017 Jun 01;31(11):1162-1176
J:251915 Geng J, et al., Regulation of RIPK1 activation by TAK1-mediated phosphorylation dictates apoptosis and necroptosis. Nat Commun. 2017 Aug 25;8(1):359
J:263339 Choi SW, et al., PELI1 Selectively Targets Kinase-Active RIP3 for Ubiquitylation-Dependent Proteasomal Degradation. Mol Cell. 2018 Jun 7;70(5):920-935.e7
J:265780 Meng H, et al., Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):E2001-E2009
J:275558 Dondelinger Y, et al., Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation. Nat Commun. 2019 Apr 15;10(1):1729
J:279199 Ingram JP, et al., ZBP1/DAI Drives RIPK3-Mediated Cell Death Induced by IFNs in the Absence of RIPK1. J Immunol. 2019 Sep 1;203(5):1348-1355
J:279494 Tang Y, et al., K63-linked ubiquitination regulates RIPK1 kinase activity to prevent cell death during embryogenesis and inflammation. Nat Commun. 2019 Sep 13;10(1):4157
J:280188 Zhang X, et al., RIPK1 can mediate apoptosis in addition to necroptosis during embryonic development. Cell Death Dis. 2019 Mar 13;10(3):245
J:281166 Zhang X, et al., Ubiquitination of RIPK1 suppresses programmed cell death by regulating RIPK1 kinase activation during embryogenesis. Nat Commun. 2019 Sep 13;10(1):4158
J:281201 Anderton H, et al., RIPK1 prevents TRADD-driven, but TNFR1 independent, apoptosis during development. Cell Death Differ. 2019 May;26(5):877-889
J:281456 Newton K, et al., Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis. Nature. 2019 Oct;574(7778):428-431
J:285926 Lalaoui N, et al., Mutations that prevent caspase cleavage of RIPK1 cause autoinflammatory disease. Nature. 2020 Jan;577(7788):103-108
J:291245 Tao P, et al., A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1. Nature. 2020 Jan;577(7788):109-114
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:300952 Muendlein HI, et al., ZBP1 promotes LPS-induced cell death and IL-1beta release via RHIM-mediated interactions with RIPK1. Nat Commun. 2021 Jan 4;12(1):86
J:361095 Lee S, et al., AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence. Nature. 2021 Sep;597(7876):415-419